Gentisyl alcohol, an antioxidant from microbial metabolite, induces angiogenesis in vitro

Hye Jin Kim, Jin Hee Kim, Choong Hwan Lee, Ho Jeong Kwon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Gentisyl alcohol isolated from Penicillium sp. has an antioxidative activity, protecting cells from oxidative stresses. From our in vitro angiogenesis assays with bovine aortic endothelial cells (BAECs), gentisyl alcohol was newly identified as a pro-angiogenic small molecule that induces new blood vessel formation of the cells. Gentisyl alcohol stimulated the proliferation of BAECs in a dose-dependent manner. Moreover, it induced in vitro angiogenesis of BAECs such as invasiveness, migration, and tube formation of the endothelial cells. Effects of gentisyl alcohol on invasion and tube formation were also dose-dependent. These results demonstrate that gentisyl alcohol could affect the angiogenic phenotypes of endothelial cells and be developed as a new small molecule with pro-angiogenic activity.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalJournal of microbiology and biotechnology
Volume16
Issue number3
Publication statusPublished - 2006 Mar 1

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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