Abstract
Recently, 2D nanomaterials have received considerable attention in nanomedicine due to their intrinsic optical properties, biocompatibility, and therapeutic effect. Here, 2D germanium telluride (GeTe) nanosheets coated with polyvinylpyrrolidone (PVP) (GeTe-PVP NSs) developed as theranostic agents are reported that can be used for multispectral optoacoustic tomography (MSOT) and fluorescence imaging and therapy of inflammatory bowel disease (IBD). GeTe-PVP NSs, fabricated by simple sonication in ethanol and PVP, show broad optical absorption in visible and near-infrared (NIR) ranges (400–1200 nm) and have intrinsic fluorescence properties. Thus, they provide deeper ex vivo and in vivo MSOT tissue images than gold nanorods or indocyanine green with strong optical absorption in the first NIR window (700–900 nm). In addition, when orally administered to IBD mice, GeTe-PVP NSs exhibit therapeutic efficacy similar to or higher than sulfasalazine, with strong accumulation at inflammatory colon sites. This demonstrates that oral administration of GeTe-PVP NSs may be used to treat inflammatory diseases in the gastrointestinal tract.
| Original language | English |
|---|---|
| Article number | 2107433 |
| Journal | Advanced Functional Materials |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2022 Jan 10 |
Bibliographical note
Funding Information:J.H.S., T.Y., and S.-M.L. contributed equally to this work. This study was supported by the grant of the Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C1324) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, Republic of Korea (Grant nos. 2020R1A202011942 and 2020R1A2C1006092) and by the Ministry of Education (2019R1I1A1A01064332). All procedures involving animals were performed in accordance with the Laboratory Animals Welfare Act, the Guide for the Care and Use of Laboratory Animals, and the Guidelines and Policies for Rodent Experiments provided by the Institutional Animal Care and Use Committee of Yonsei University Severance Hospital, Seoul, Republic of Korea (IACUC approval number: 2019-0279).
Funding Information:
J.H.S., T.Y., and S.‐M.L. contributed equally to this work. This study was supported by the grant of the Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C1324) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, Republic of Korea (Grant nos. 2020R1A202011942 and 2020R1A2C1006092) and by the Ministry of Education (2019R1I1A1A01064332). All procedures involving animals were performed in accordance with the Laboratory Animals Welfare Act, the Guide for the Care and Use of Laboratory Animals, and the Guidelines and Policies for Rodent Experiments provided by the Institutional Animal Care and Use Committee of Yonsei University Severance Hospital, Seoul, Republic of Korea (IACUC approval number: 2019‐0279).
Publisher Copyright:
© 2021 Wiley-VCH GmbH
All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Materials Science(all)
- Condensed Matter Physics