Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma

Seong Hee Shim, Joon Mo Kim, Chul Young Choi, Chan Yun Kim, Ki Ho Park

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Ginkgo biloba extract (GBE) and anthocyanins are considered beneficial for various vascular diseases. This study was performed to evaluate the effect of GBE and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage. Retrospective analysis was carried out by a chart review of 332 subjects (209 men and 123 women) who were treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97). Humphrey Visual Field (HVF) test, logarithm of the minimal angle of resolution best-corrected visual acuity (logMAR BCVA), intraocular pressure, blood pressure, and fasting blood glucose were determined before and after treatment. Complete ocular and systemic examinations were performed. The mean follow-up duration was 23.82±9.84 (range, 12-59) months; the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months. After anthocyanin treatment, the mean BCVA for all eyes improved from 0.16 (±0.34) to 0.11 (±0.18) logMAR units (P=.008), and HVF mean deviation improved from -6.44 (±7.05) to -5.34 (±6.42) (P=.001). After GBE treatment, HVF mean deviation improved from -5.25 (±6.13) to -4.31 (±5.60) (P=.002). A generalized linear model demonstrated that the final BCVA was not affected by demographic differences among the groups. These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG.

Original languageEnglish
Pages (from-to)818-823
Number of pages6
JournalJournal of medicinal food
Volume15
Issue number9
DOIs
Publication statusPublished - 2012 Sep 1

Fingerprint

Vaccinium myrtillus
Low Tension Glaucoma
Ginkgo biloba
Anthocyanins
Visual Fields
Therapeutics
Visual Field Tests
Optic Nerve
Intraocular Pressure
Vascular Diseases
Visual Acuity
Blood Vessels
Blood Glucose
Linear Models
Fasting
Demography
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Shim, Seong Hee ; Kim, Joon Mo ; Choi, Chul Young ; Kim, Chan Yun ; Park, Ki Ho. / Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. In: Journal of medicinal food. 2012 ; Vol. 15, No. 9. pp. 818-823.
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abstract = "Ginkgo biloba extract (GBE) and anthocyanins are considered beneficial for various vascular diseases. This study was performed to evaluate the effect of GBE and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage. Retrospective analysis was carried out by a chart review of 332 subjects (209 men and 123 women) who were treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97). Humphrey Visual Field (HVF) test, logarithm of the minimal angle of resolution best-corrected visual acuity (logMAR BCVA), intraocular pressure, blood pressure, and fasting blood glucose were determined before and after treatment. Complete ocular and systemic examinations were performed. The mean follow-up duration was 23.82±9.84 (range, 12-59) months; the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months. After anthocyanin treatment, the mean BCVA for all eyes improved from 0.16 (±0.34) to 0.11 (±0.18) logMAR units (P=.008), and HVF mean deviation improved from -6.44 (±7.05) to -5.34 (±6.42) (P=.001). After GBE treatment, HVF mean deviation improved from -5.25 (±6.13) to -4.31 (±5.60) (P=.002). A generalized linear model demonstrated that the final BCVA was not affected by demographic differences among the groups. These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG.",
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Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. / Shim, Seong Hee; Kim, Joon Mo; Choi, Chul Young; Kim, Chan Yun; Park, Ki Ho.

In: Journal of medicinal food, Vol. 15, No. 9, 01.09.2012, p. 818-823.

Research output: Contribution to journalArticle

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