Glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection

Sang Kyum Kim, Hyo Sup Shim, Kwang Gil Lee, Hee Jung An, Kyung Rhul Lee, Nam Hoon Cho

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Glassy cell carcinoma (GCC) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. This study includes immunoprofiles of p63, cytokeratin 17 (CK17), and CD44 to clarify which lineage of GCC is committed to human papillomavirus (HPV) detection, and to verify whether or not HPV plays a role in GCC. Nine uterine GCCs showing overwhelmingly glassy features were evaluated by an HPV genotyping chip and by immunohistochemistry for E-cadherin, CD44, p63, CEA, erb-B2, cytokeratin 17, and p16. An HPV genotyping DNA chip array with multiple oligonucleotide probes of L1 sequences from 26 types of HPV was introduced. GCCs were variably stained, except for CD44 which was stained unanimously. A lack of E-cadherin was found in 4 cases, frequent expression of p63 in 6/9 (66.7%), mucin stain or CEA in 5/9 (55.6%), and coexpression of p63 in 4. HPV prevalence in GCC was found in 6/9 cases (66.7%). HPV-18 and HPV-32 were the most common types detected. The remaining cancers were infected by HPV-31, HPV-35, HPV-39, and HPV-68. Multiple infections were found in 2 out of 6 cases. GCC could not be precisely categorized, but was committed to squamous lineages and was strongly associated with high-risk type HPV infection.

Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume28
Issue number4
DOIs
Publication statusPublished - 2009 Jul 1

Fingerprint

Papillomavirus Infections
Carcinoma
Keratin-17
Cadherins
Oligonucleotide Array Sequence Analysis
Human papillomavirus 31
Adenosquamous Carcinoma
Human papillomavirus 18
Oligonucleotide Probes
Mucins
Coloring Agents
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

Cite this

@article{071828de810e497fa5427656aeb860dc,
title = "Glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection",
abstract = "Glassy cell carcinoma (GCC) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. This study includes immunoprofiles of p63, cytokeratin 17 (CK17), and CD44 to clarify which lineage of GCC is committed to human papillomavirus (HPV) detection, and to verify whether or not HPV plays a role in GCC. Nine uterine GCCs showing overwhelmingly glassy features were evaluated by an HPV genotyping chip and by immunohistochemistry for E-cadherin, CD44, p63, CEA, erb-B2, cytokeratin 17, and p16. An HPV genotyping DNA chip array with multiple oligonucleotide probes of L1 sequences from 26 types of HPV was introduced. GCCs were variably stained, except for CD44 which was stained unanimously. A lack of E-cadherin was found in 4 cases, frequent expression of p63 in 6/9 (66.7{\%}), mucin stain or CEA in 5/9 (55.6{\%}), and coexpression of p63 in 4. HPV prevalence in GCC was found in 6/9 cases (66.7{\%}). HPV-18 and HPV-32 were the most common types detected. The remaining cancers were infected by HPV-31, HPV-35, HPV-39, and HPV-68. Multiple infections were found in 2 out of 6 cases. GCC could not be precisely categorized, but was committed to squamous lineages and was strongly associated with high-risk type HPV infection.",
author = "Kim, {Sang Kyum} and Shim, {Hyo Sup} and Lee, {Kwang Gil} and An, {Hee Jung} and Lee, {Kyung Rhul} and Cho, {Nam Hoon}",
year = "2009",
month = "7",
day = "1",
doi = "10.1097/PGP.0b013e31819343a5",
language = "English",
volume = "28",
pages = "389--395",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection. / Kim, Sang Kyum; Shim, Hyo Sup; Lee, Kwang Gil; An, Hee Jung; Lee, Kyung Rhul; Cho, Nam Hoon.

In: International Journal of Gynecological Pathology, Vol. 28, No. 4, 01.07.2009, p. 389-395.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection

AU - Kim, Sang Kyum

AU - Shim, Hyo Sup

AU - Lee, Kwang Gil

AU - An, Hee Jung

AU - Lee, Kyung Rhul

AU - Cho, Nam Hoon

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Glassy cell carcinoma (GCC) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. This study includes immunoprofiles of p63, cytokeratin 17 (CK17), and CD44 to clarify which lineage of GCC is committed to human papillomavirus (HPV) detection, and to verify whether or not HPV plays a role in GCC. Nine uterine GCCs showing overwhelmingly glassy features were evaluated by an HPV genotyping chip and by immunohistochemistry for E-cadherin, CD44, p63, CEA, erb-B2, cytokeratin 17, and p16. An HPV genotyping DNA chip array with multiple oligonucleotide probes of L1 sequences from 26 types of HPV was introduced. GCCs were variably stained, except for CD44 which was stained unanimously. A lack of E-cadherin was found in 4 cases, frequent expression of p63 in 6/9 (66.7%), mucin stain or CEA in 5/9 (55.6%), and coexpression of p63 in 4. HPV prevalence in GCC was found in 6/9 cases (66.7%). HPV-18 and HPV-32 were the most common types detected. The remaining cancers were infected by HPV-31, HPV-35, HPV-39, and HPV-68. Multiple infections were found in 2 out of 6 cases. GCC could not be precisely categorized, but was committed to squamous lineages and was strongly associated with high-risk type HPV infection.

AB - Glassy cell carcinoma (GCC) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. This study includes immunoprofiles of p63, cytokeratin 17 (CK17), and CD44 to clarify which lineage of GCC is committed to human papillomavirus (HPV) detection, and to verify whether or not HPV plays a role in GCC. Nine uterine GCCs showing overwhelmingly glassy features were evaluated by an HPV genotyping chip and by immunohistochemistry for E-cadherin, CD44, p63, CEA, erb-B2, cytokeratin 17, and p16. An HPV genotyping DNA chip array with multiple oligonucleotide probes of L1 sequences from 26 types of HPV was introduced. GCCs were variably stained, except for CD44 which was stained unanimously. A lack of E-cadherin was found in 4 cases, frequent expression of p63 in 6/9 (66.7%), mucin stain or CEA in 5/9 (55.6%), and coexpression of p63 in 4. HPV prevalence in GCC was found in 6/9 cases (66.7%). HPV-18 and HPV-32 were the most common types detected. The remaining cancers were infected by HPV-31, HPV-35, HPV-39, and HPV-68. Multiple infections were found in 2 out of 6 cases. GCC could not be precisely categorized, but was committed to squamous lineages and was strongly associated with high-risk type HPV infection.

UR - http://www.scopus.com/inward/record.url?scp=69049115104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69049115104&partnerID=8YFLogxK

U2 - 10.1097/PGP.0b013e31819343a5

DO - 10.1097/PGP.0b013e31819343a5

M3 - Article

C2 - 19483622

AN - SCOPUS:69049115104

VL - 28

SP - 389

EP - 395

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

IS - 4

ER -