TY - JOUR
T1 - Glaucoma diagnostic value of the total macular thickness and ganglion cell-inner plexiform layer thickness according to optic disc area
AU - Yoon, Myung Hun
AU - Park, Sang Jun
AU - Kim, Chan Yun
AU - Chin, Hee Seung
AU - Kim, Na Rae
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/3
Y1 - 2014/3
N2 - Aims: This study examined the diagnostic value of the perimacular ganglion cell-inner plexiform layer (GCIPL) thickness in the detection of glaucoma according to the optic disc area. Methods: The participants underwent reliable standard automated perimetry tests and Cirrus optical coherence tomography. The area under the receiver operating characteristic curve (AUC) was used to determine the diagnostic ability of the GCIPL, total macular thickness, retinal nerve fibre layer (RNFL) and optic nerve head parameters. Subsequently, optic disc areas of ≤1.9, ≤2.4 and >2.4 mm2 were chosen arbitrarily, and the AUCs and sensitivities at fixed specificities were compared for each. Results: 87 normal subjects and 96 glaucoma patients were enrolled. The mean GCIPL thickness and RNFL showed similar ability to diagnose glaucoma (p=0.911). The mean GCIPL thickness had higher diagnostic ability than the central retinal subfield thickness (p=0.001), comparable with that of the retinal cube volume (p=0.840) and mean retinal cube thickness ( p=0.840). The mean RNFL (0.866), the minimum GCIPL (0.840) and the inferior and inferotemporal (0.853) disc had the highest AUCs for small, medium and large discs, respectively. Conclusions: The macular GCIPL thickness, total macular cube thickness, circumpapillary RNFL thickness and disc rim area showed similar performance in diagnosing glaucoma, irrespective of the optic disc size.
AB - Aims: This study examined the diagnostic value of the perimacular ganglion cell-inner plexiform layer (GCIPL) thickness in the detection of glaucoma according to the optic disc area. Methods: The participants underwent reliable standard automated perimetry tests and Cirrus optical coherence tomography. The area under the receiver operating characteristic curve (AUC) was used to determine the diagnostic ability of the GCIPL, total macular thickness, retinal nerve fibre layer (RNFL) and optic nerve head parameters. Subsequently, optic disc areas of ≤1.9, ≤2.4 and >2.4 mm2 were chosen arbitrarily, and the AUCs and sensitivities at fixed specificities were compared for each. Results: 87 normal subjects and 96 glaucoma patients were enrolled. The mean GCIPL thickness and RNFL showed similar ability to diagnose glaucoma (p=0.911). The mean GCIPL thickness had higher diagnostic ability than the central retinal subfield thickness (p=0.001), comparable with that of the retinal cube volume (p=0.840) and mean retinal cube thickness ( p=0.840). The mean RNFL (0.866), the minimum GCIPL (0.840) and the inferior and inferotemporal (0.853) disc had the highest AUCs for small, medium and large discs, respectively. Conclusions: The macular GCIPL thickness, total macular cube thickness, circumpapillary RNFL thickness and disc rim area showed similar performance in diagnosing glaucoma, irrespective of the optic disc size.
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U2 - 10.1136/bjophthalmol-2013-303185
DO - 10.1136/bjophthalmol-2013-303185
M3 - Article
C2 - 24385290
AN - SCOPUS:84894044959
VL - 98
SP - 315
EP - 321
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 3
ER -