Glomerular C4d deposition indicates in situ classic complement pathway activation, but is not a marker for lupus nephritis activity

SeHoon Kim, Hyeon Joo Jeong

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This study was designed to evaluate whether glomerular C4d deposition may be a useful marker of lupus nephritis activity. Twenty-one patients diagnosed as having lupus nephritis (WHO class III: 4 cases; IV: 12 cases; V: 5 cases) were included. Mean patient age was 29.3 ± 13.5 years (range: 7-55 years). The presence and intensity of glomerular C4d deposition were compared with the corresponding histologic activity index for each case. Immunofluorescence for C4d showed diffusely granular staining along glomerular capillary loops, in all cases examined (1+, in 8 cases; 2+, in 7 cases; 3+, in 6cases). In eight cases, C4d deposition was found in the absence of capillary or mesangial C4 deposits. Moreover, the intensity of C4d deposits correlated with those of capillary IgG, IgA, C4, C1q, and fibrinogen deposits. However, C4d staining intensity did not correlate with the 1upus nephritis activity index. Although glomerular capillary C4d deposition is a sensitive marker of classic complement pathway activation, it is not a sensitive marker for active lupus nephritis.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalYonsei medical journal
Volume44
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1

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Lupus Nephritis
Complement Activation
Staining and Labeling
Nephritis
Fibrinogen
Immunoglobulin A
Fluorescent Antibody Technique
Immunoglobulin G

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "This study was designed to evaluate whether glomerular C4d deposition may be a useful marker of lupus nephritis activity. Twenty-one patients diagnosed as having lupus nephritis (WHO class III: 4 cases; IV: 12 cases; V: 5 cases) were included. Mean patient age was 29.3 ± 13.5 years (range: 7-55 years). The presence and intensity of glomerular C4d deposition were compared with the corresponding histologic activity index for each case. Immunofluorescence for C4d showed diffusely granular staining along glomerular capillary loops, in all cases examined (1+, in 8 cases; 2+, in 7 cases; 3+, in 6cases). In eight cases, C4d deposition was found in the absence of capillary or mesangial C4 deposits. Moreover, the intensity of C4d deposits correlated with those of capillary IgG, IgA, C4, C1q, and fibrinogen deposits. However, C4d staining intensity did not correlate with the 1upus nephritis activity index. Although glomerular capillary C4d deposition is a sensitive marker of classic complement pathway activation, it is not a sensitive marker for active lupus nephritis.",
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Glomerular C4d deposition indicates in situ classic complement pathway activation, but is not a marker for lupus nephritis activity. / Kim, SeHoon; Jeong, Hyeon Joo.

In: Yonsei medical journal, Vol. 44, No. 1, 01.01.2003, p. 75-80.

Research output: Contribution to journalArticle

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