Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy

Dong Ho Shin, Beom Jin Lim, In Mi Han, Seung Gyu Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Shin Wook Kang, Tae Hyun Yoo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Glomerular IgG deposition is frequently observed in patients with IgA nephropathy. However, the association between glomerular IgG deposition and progression of IgA nephropathy is uncertain. Six hundred and twenty-seven patients with biopsy-proven IgA nephropathy were recruited. Histological variables of the Oxford classification (Oxford-MEST) and the presence of glomerular IgG deposits were assessed. Renal progression defined as end-stage renal disease or 50% reduction in estimated glomerular filtration rate was analyzed using Kaplan-Meier methods and Cox regression analysis. Of the study population, 200 patients (31.9%) had glomerular IgG deposition on immunofluorescence staining. During a mean follow-up of 56.8±37.5 months, the rate of renal progression was significantly higher in the IgA nephropathy patients with glomerular IgG deposition compared with the IgA nephropathy patients without glomerular IgG deposition (39.8 vs 12.3 per 1000 patient-years; P<0.001). Of patients with IgG deposition, 178 (28.3%), 20 (3.2%), and 2 (0.3%) patients had mild, moderate, and marked glomerular IgG deposits, receptively. Kaplan-Meier analysis revealed that cumulative renal survival was significantly lower in IgA nephropathy patients with the higher intensity of glomerular IgG deposits (P<0.001). In addition, Cox regression analysis revealed that moderate and marked glomerular IgG deposits significantly predicted renal outcome independent of Oxford-MEST and clinical variables (HR, 2.97; 95% CI, 1.01-8.77; P=0.04). This study showed that that glomerular IgG deposition was independently associated with poor renal outcome in patient with IgA nephropathy.

Original languageEnglish
Pages (from-to)743-752
Number of pages10
JournalModern Pathology
Volume29
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

Fingerprint

Immunoglobulin A
Immunoglobulin G
Kidney
Regression Analysis
Kaplan-Meier Estimate
Glomerular Filtration Rate
Chronic Kidney Failure
Fluorescent Antibody Technique
Staining and Labeling
Biopsy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Shin, Dong Ho ; Lim, Beom Jin ; Han, In Mi ; Han, Seung Gyu ; Kwon, Young Eun ; Park, Kyoung Sook ; Lee, Mi Jung ; Oh, Hyung Jung ; Park, Jung Tak ; Han, Seung Hyeok ; Kang, Shin Wook ; Yoo, Tae Hyun. / Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy. In: Modern Pathology. 2016 ; Vol. 29, No. 7. pp. 743-752.
@article{d25072867ba3464393431b08dadd0f2c,
title = "Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy",
abstract = "Glomerular IgG deposition is frequently observed in patients with IgA nephropathy. However, the association between glomerular IgG deposition and progression of IgA nephropathy is uncertain. Six hundred and twenty-seven patients with biopsy-proven IgA nephropathy were recruited. Histological variables of the Oxford classification (Oxford-MEST) and the presence of glomerular IgG deposits were assessed. Renal progression defined as end-stage renal disease or 50{\%} reduction in estimated glomerular filtration rate was analyzed using Kaplan-Meier methods and Cox regression analysis. Of the study population, 200 patients (31.9{\%}) had glomerular IgG deposition on immunofluorescence staining. During a mean follow-up of 56.8±37.5 months, the rate of renal progression was significantly higher in the IgA nephropathy patients with glomerular IgG deposition compared with the IgA nephropathy patients without glomerular IgG deposition (39.8 vs 12.3 per 1000 patient-years; P<0.001). Of patients with IgG deposition, 178 (28.3{\%}), 20 (3.2{\%}), and 2 (0.3{\%}) patients had mild, moderate, and marked glomerular IgG deposits, receptively. Kaplan-Meier analysis revealed that cumulative renal survival was significantly lower in IgA nephropathy patients with the higher intensity of glomerular IgG deposits (P<0.001). In addition, Cox regression analysis revealed that moderate and marked glomerular IgG deposits significantly predicted renal outcome independent of Oxford-MEST and clinical variables (HR, 2.97; 95{\%} CI, 1.01-8.77; P=0.04). This study showed that that glomerular IgG deposition was independently associated with poor renal outcome in patient with IgA nephropathy.",
author = "Shin, {Dong Ho} and Lim, {Beom Jin} and Han, {In Mi} and Han, {Seung Gyu} and Kwon, {Young Eun} and Park, {Kyoung Sook} and Lee, {Mi Jung} and Oh, {Hyung Jung} and Park, {Jung Tak} and Han, {Seung Hyeok} and Kang, {Shin Wook} and Yoo, {Tae Hyun}",
year = "2016",
month = "7",
day = "1",
doi = "10.1038/modpathol.2016.77",
language = "English",
volume = "29",
pages = "743--752",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "7",

}

Shin, DH, Lim, BJ, Han, IM, Han, SG, Kwon, YE, Park, KS, Lee, MJ, Oh, HJ, Park, JT, Han, SH, Kang, SW & Yoo, TH 2016, 'Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy', Modern Pathology, vol. 29, no. 7, pp. 743-752. https://doi.org/10.1038/modpathol.2016.77

Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy. / Shin, Dong Ho; Lim, Beom Jin; Han, In Mi; Han, Seung Gyu; Kwon, Young Eun; Park, Kyoung Sook; Lee, Mi Jung; Oh, Hyung Jung; Park, Jung Tak; Han, Seung Hyeok; Kang, Shin Wook; Yoo, Tae Hyun.

In: Modern Pathology, Vol. 29, No. 7, 01.07.2016, p. 743-752.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy

AU - Shin, Dong Ho

AU - Lim, Beom Jin

AU - Han, In Mi

AU - Han, Seung Gyu

AU - Kwon, Young Eun

AU - Park, Kyoung Sook

AU - Lee, Mi Jung

AU - Oh, Hyung Jung

AU - Park, Jung Tak

AU - Han, Seung Hyeok

AU - Kang, Shin Wook

AU - Yoo, Tae Hyun

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Glomerular IgG deposition is frequently observed in patients with IgA nephropathy. However, the association between glomerular IgG deposition and progression of IgA nephropathy is uncertain. Six hundred and twenty-seven patients with biopsy-proven IgA nephropathy were recruited. Histological variables of the Oxford classification (Oxford-MEST) and the presence of glomerular IgG deposits were assessed. Renal progression defined as end-stage renal disease or 50% reduction in estimated glomerular filtration rate was analyzed using Kaplan-Meier methods and Cox regression analysis. Of the study population, 200 patients (31.9%) had glomerular IgG deposition on immunofluorescence staining. During a mean follow-up of 56.8±37.5 months, the rate of renal progression was significantly higher in the IgA nephropathy patients with glomerular IgG deposition compared with the IgA nephropathy patients without glomerular IgG deposition (39.8 vs 12.3 per 1000 patient-years; P<0.001). Of patients with IgG deposition, 178 (28.3%), 20 (3.2%), and 2 (0.3%) patients had mild, moderate, and marked glomerular IgG deposits, receptively. Kaplan-Meier analysis revealed that cumulative renal survival was significantly lower in IgA nephropathy patients with the higher intensity of glomerular IgG deposits (P<0.001). In addition, Cox regression analysis revealed that moderate and marked glomerular IgG deposits significantly predicted renal outcome independent of Oxford-MEST and clinical variables (HR, 2.97; 95% CI, 1.01-8.77; P=0.04). This study showed that that glomerular IgG deposition was independently associated with poor renal outcome in patient with IgA nephropathy.

AB - Glomerular IgG deposition is frequently observed in patients with IgA nephropathy. However, the association between glomerular IgG deposition and progression of IgA nephropathy is uncertain. Six hundred and twenty-seven patients with biopsy-proven IgA nephropathy were recruited. Histological variables of the Oxford classification (Oxford-MEST) and the presence of glomerular IgG deposits were assessed. Renal progression defined as end-stage renal disease or 50% reduction in estimated glomerular filtration rate was analyzed using Kaplan-Meier methods and Cox regression analysis. Of the study population, 200 patients (31.9%) had glomerular IgG deposition on immunofluorescence staining. During a mean follow-up of 56.8±37.5 months, the rate of renal progression was significantly higher in the IgA nephropathy patients with glomerular IgG deposition compared with the IgA nephropathy patients without glomerular IgG deposition (39.8 vs 12.3 per 1000 patient-years; P<0.001). Of patients with IgG deposition, 178 (28.3%), 20 (3.2%), and 2 (0.3%) patients had mild, moderate, and marked glomerular IgG deposits, receptively. Kaplan-Meier analysis revealed that cumulative renal survival was significantly lower in IgA nephropathy patients with the higher intensity of glomerular IgG deposits (P<0.001). In addition, Cox regression analysis revealed that moderate and marked glomerular IgG deposits significantly predicted renal outcome independent of Oxford-MEST and clinical variables (HR, 2.97; 95% CI, 1.01-8.77; P=0.04). This study showed that that glomerular IgG deposition was independently associated with poor renal outcome in patient with IgA nephropathy.

UR - http://www.scopus.com/inward/record.url?scp=84964292724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964292724&partnerID=8YFLogxK

U2 - 10.1038/modpathol.2016.77

DO - 10.1038/modpathol.2016.77

M3 - Article

C2 - 27102346

AN - SCOPUS:84964292724

VL - 29

SP - 743

EP - 752

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 7

ER -