Glucagon Levels, Disease Severity, and Outcome in Severe Sepsis

Won Jai Jung, Byung Hoon Park, Kyung Soo Chung, Song Yee Kim, Eun Young Kim, Ji Ye Jung, youngae kang, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park

Research output: Contribution to journalArticle

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Abstract

Purpose: Few studies on plasma glucagon levels in patients with sepsis have been performed. We aimed to assess clinical value of glucagon levels in comparison with clinical parameters and severity scores in patients with severe sepsis or septic shock. Methods: A total of 112 patients who were admitted to intensive care unit with severe sepsis or septic shock were included. Plasma levels of glucagon on days 0, 1, 3, and 7 were serially measured in 112 patients with severe sepsis or septic shock. Results: Compared with survivors, patients who died within 28 days had significantly higher glucagon levels on every day of examination. Glucagon levels were positively correlated with and Acute Physiology and Chronic Health Evaluation II score (day 0, r = 0.288, P < 0.01) and Sequential Organ Failure Assessment (day 0, r = 0.482, P< 0.01; day 1, r = 0.588, P < 0.01; day 3, r = 0.480, P < 0.01; day 7, r = 0.454, P < 0.01). Receiver operating characteristic analysis showed that the area under the curve of glucagon levels to predict 28-day survival was 0.65 (95% confidence interval [CI], 0.55-0.75; P = 0.005), similar to the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores. Multivariate analysis revealed that glucagon levels of greater than 70 pg/mL (hazard ratio, 1.85; 95% CI, 1.03-3.29) and chronic liver disease (hazard ratio, 1.97; 95% CI, 1.02-3.79) were associated with mortality. Conclusions: Glucagon levels might reflect disease severity and clinical outcomes in patients with severe sepsis or septic shock.

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalShock
Volume43
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

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Glucagon
Sepsis
Septic Shock
APACHE
Confidence Intervals
Organ Dysfunction Scores
ROC Curve
Area Under Curve
Intensive Care Units
Survivors
Liver Diseases
Chronic Disease
Multivariate Analysis
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Jung, W. J., Park, B. H., Chung, K. S., Kim, S. Y., Kim, E. Y., Jung, J. Y., ... Park, M. S. (2015). Glucagon Levels, Disease Severity, and Outcome in Severe Sepsis. Shock, 43(6), 563-568. https://doi.org/10.1097/SHK.0000000000000344
Jung, Won Jai ; Park, Byung Hoon ; Chung, Kyung Soo ; Kim, Song Yee ; Kim, Eun Young ; Jung, Ji Ye ; kang, youngae ; Kim, Young Sam ; Kim, Se Kyu ; Chang, Joon ; Park, Moo Suk. / Glucagon Levels, Disease Severity, and Outcome in Severe Sepsis. In: Shock. 2015 ; Vol. 43, No. 6. pp. 563-568.
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abstract = "Purpose: Few studies on plasma glucagon levels in patients with sepsis have been performed. We aimed to assess clinical value of glucagon levels in comparison with clinical parameters and severity scores in patients with severe sepsis or septic shock. Methods: A total of 112 patients who were admitted to intensive care unit with severe sepsis or septic shock were included. Plasma levels of glucagon on days 0, 1, 3, and 7 were serially measured in 112 patients with severe sepsis or septic shock. Results: Compared with survivors, patients who died within 28 days had significantly higher glucagon levels on every day of examination. Glucagon levels were positively correlated with and Acute Physiology and Chronic Health Evaluation II score (day 0, r = 0.288, P < 0.01) and Sequential Organ Failure Assessment (day 0, r = 0.482, P< 0.01; day 1, r = 0.588, P < 0.01; day 3, r = 0.480, P < 0.01; day 7, r = 0.454, P < 0.01). Receiver operating characteristic analysis showed that the area under the curve of glucagon levels to predict 28-day survival was 0.65 (95{\%} confidence interval [CI], 0.55-0.75; P = 0.005), similar to the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores. Multivariate analysis revealed that glucagon levels of greater than 70 pg/mL (hazard ratio, 1.85; 95{\%} CI, 1.03-3.29) and chronic liver disease (hazard ratio, 1.97; 95{\%} CI, 1.02-3.79) were associated with mortality. Conclusions: Glucagon levels might reflect disease severity and clinical outcomes in patients with severe sepsis or septic shock.",
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Jung, WJ, Park, BH, Chung, KS, Kim, SY, Kim, EY, Jung, JY, kang, Y, Kim, YS, Kim, SK, Chang, J & Park, MS 2015, 'Glucagon Levels, Disease Severity, and Outcome in Severe Sepsis', Shock, vol. 43, no. 6, pp. 563-568. https://doi.org/10.1097/SHK.0000000000000344

Glucagon Levels, Disease Severity, and Outcome in Severe Sepsis. / Jung, Won Jai; Park, Byung Hoon; Chung, Kyung Soo; Kim, Song Yee; Kim, Eun Young; Jung, Ji Ye; kang, youngae; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Park, Moo Suk.

In: Shock, Vol. 43, No. 6, 01.01.2015, p. 563-568.

Research output: Contribution to journalArticle

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T1 - Glucagon Levels, Disease Severity, and Outcome in Severe Sepsis

AU - Jung, Won Jai

AU - Park, Byung Hoon

AU - Chung, Kyung Soo

AU - Kim, Song Yee

AU - Kim, Eun Young

AU - Jung, Ji Ye

AU - kang, youngae

AU - Kim, Young Sam

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Park, Moo Suk

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: Few studies on plasma glucagon levels in patients with sepsis have been performed. We aimed to assess clinical value of glucagon levels in comparison with clinical parameters and severity scores in patients with severe sepsis or septic shock. Methods: A total of 112 patients who were admitted to intensive care unit with severe sepsis or septic shock were included. Plasma levels of glucagon on days 0, 1, 3, and 7 were serially measured in 112 patients with severe sepsis or septic shock. Results: Compared with survivors, patients who died within 28 days had significantly higher glucagon levels on every day of examination. Glucagon levels were positively correlated with and Acute Physiology and Chronic Health Evaluation II score (day 0, r = 0.288, P < 0.01) and Sequential Organ Failure Assessment (day 0, r = 0.482, P< 0.01; day 1, r = 0.588, P < 0.01; day 3, r = 0.480, P < 0.01; day 7, r = 0.454, P < 0.01). Receiver operating characteristic analysis showed that the area under the curve of glucagon levels to predict 28-day survival was 0.65 (95% confidence interval [CI], 0.55-0.75; P = 0.005), similar to the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores. Multivariate analysis revealed that glucagon levels of greater than 70 pg/mL (hazard ratio, 1.85; 95% CI, 1.03-3.29) and chronic liver disease (hazard ratio, 1.97; 95% CI, 1.02-3.79) were associated with mortality. Conclusions: Glucagon levels might reflect disease severity and clinical outcomes in patients with severe sepsis or septic shock.

AB - Purpose: Few studies on plasma glucagon levels in patients with sepsis have been performed. We aimed to assess clinical value of glucagon levels in comparison with clinical parameters and severity scores in patients with severe sepsis or septic shock. Methods: A total of 112 patients who were admitted to intensive care unit with severe sepsis or septic shock were included. Plasma levels of glucagon on days 0, 1, 3, and 7 were serially measured in 112 patients with severe sepsis or septic shock. Results: Compared with survivors, patients who died within 28 days had significantly higher glucagon levels on every day of examination. Glucagon levels were positively correlated with and Acute Physiology and Chronic Health Evaluation II score (day 0, r = 0.288, P < 0.01) and Sequential Organ Failure Assessment (day 0, r = 0.482, P< 0.01; day 1, r = 0.588, P < 0.01; day 3, r = 0.480, P < 0.01; day 7, r = 0.454, P < 0.01). Receiver operating characteristic analysis showed that the area under the curve of glucagon levels to predict 28-day survival was 0.65 (95% confidence interval [CI], 0.55-0.75; P = 0.005), similar to the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores. Multivariate analysis revealed that glucagon levels of greater than 70 pg/mL (hazard ratio, 1.85; 95% CI, 1.03-3.29) and chronic liver disease (hazard ratio, 1.97; 95% CI, 1.02-3.79) were associated with mortality. Conclusions: Glucagon levels might reflect disease severity and clinical outcomes in patients with severe sepsis or septic shock.

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Jung WJ, Park BH, Chung KS, Kim SY, Kim EY, Jung JY et al. Glucagon Levels, Disease Severity, and Outcome in Severe Sepsis. Shock. 2015 Jan 1;43(6):563-568. https://doi.org/10.1097/SHK.0000000000000344