Glucose and glutamine metabolism-related protein expression in breast ductal carcinoma in situ

Hyang Joo Ryu, Ja Seung Koo

Research output: Contribution to journalArticlepeer-review


Glucose and glutamine metabolism is involved in important tumor mechanisms. Metabolism-related protein expression has been previously reported to predict tumor prognosis. We aimed to investigate glucose and glutamine metabolism-related protein expression and its implication in breast ductal carcinoma in situ (DCIS). A tissue microarray was prepared for 205 DCIS cases. Glucose and glutamine metabolism-related proteins were immunostained. Based on the results of estrogen receptor, progesterone receptor, human epidermal growth factor receptor (HER)-2, and Ki-67, DCIS was classified into the luminal type, HER-2 type, and triple-negative breast cancer (TNBC). DCIS stroma was classified into non-inflammatory and inflammatory types per stromal histology. DCIS (N=205) was classified into luminal type (n=112), HER-2 type (n=81), and TNBC (n=12). Hexokinase II (p=0.044), GLS (p=0.003), and SLC7A5 (p<0.001) expression rates were the highest in TNBC. Inflammatory type stroma showed higher SLC7A5 (p<0.001) and SLC7A11 (p=0.008) expression rates than non-inflammatory type stroma. In summary, DCIS demonstrated differential expression of metabolism-related proteins according to the molecular subtype and stromal features. TNBC showed the highest glucose and glutamine metabolism-related protein expression, and inflammatory type stroma showed higher glutamine metabolism-related protein expression than non-inflammatory type stroma.

Original languageEnglish
Pages (from-to)630-639
Number of pages10
Issue number3
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This study was approved by the Institutional Review Board of Severance Hospital (4-2020-1282). The informed consent from patients was exempted by IRB. This study was exempt from obtaining written informed consent due to the retrospective nature of the study.

Publisher Copyright:
© 2022, AEPress, s.r.o.. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Oncology


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