Glucosides of catechin and epigallocatechin gallate: Enzymatic synthesis to improve its biological activity

Thi Thanh Hanh Nguyen, Hee Kyoung Kang, Seong Bo Kim, Kunal Pal, Doman Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Green tea (Camellia sinensis) has attracted significant attention in both scientific and consumer communities due to its health benefits against a variety of disorders. Catechin and epigallocatechin gallate (EGCG) are the most abundant polyphenols in green tea. They have been studied for their therapeutic potential in various cancers, Alzheimer's disease, obesity, and diabetes. However, catechin and EGCG have limitations for use in foods, feeds, and pharmaceuticals due to their low solubility, easy degradation, instability in alkaline conditions, and low permeability. Catechinand EGCG-glucosides have higher water solubility compared to catechin and EGCG, respectively. They are also resistant against alteration of color (to a yellowish brown). This chapter summarizes enzymatic transglycosylation for producing novel catechinand EGCG-glucosides. Biopharmaceutical properties (such as water solubility, stability in solution, and biological activities) and structural activities of these glucosides are also discussed.

Original languageEnglish
Title of host publicationEnzymes in Food Technology
Subtitle of host publicationImprovements and Innovations
PublisherSpringer Singapore
Pages277-291
Number of pages15
ISBN (Electronic)9789811319334
ISBN (Print)9789811319327
DOIs
Publication statusPublished - 2018 Nov 19

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Health Professions(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemical Engineering(all)

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