Glutamine reliance in cell metabolism

Hee Chan Yoo; Ya Chun Yu; Yulseung Sung; Jung Min Han

doi:10.1038/s12276-020-00504-8

Glutamine reliance in cell metabolism

Hee Chan Yoo, Ya Chun Yu, Yulseung Sung, Jung Min Han

Research output: Contribution to journal › Review article › peer-review

150 Citations (Scopus)

Abstract

As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer.

Original language	English
Pages (from-to)	1496-1516
Number of pages	21
Journal	Experimental and Molecular Medicine
Volume	52
Issue number	9
DOIs	https://doi.org/10.1038/s12276-020-00504-8
Publication status	Published - 2020 Sep 1

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2018R1A6A1A03023718 and 2020R1I1A1A01067423) and by the NRF grant funded by the Korean government (MSIT) (2020M3E5E2040282). H.C.Y. was supported by the Graduate School of Yonsei University Research Scholarship Grants in 2019.

Publisher Copyright:
© 2020, The Author(s).

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s12276-020-00504-8

Cite this

@article{ea9366cd818c47dea8c07bf07fc04034,

title = "Glutamine reliance in cell metabolism",

abstract = "As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer.",

author = "Yoo, {Hee Chan} and Yu, {Ya Chun} and Yulseung Sung and Han, {Jung Min}",

note = "Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2018R1A6A1A03023718 and 2020R1I1A1A01067423) and by the NRF grant funded by the Korean government (MSIT) (2020M3E5E2040282). H.C.Y. was supported by the Graduate School of Yonsei University Research Scholarship Grants in 2019. Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = sep,

day = "1",

doi = "10.1038/s12276-020-00504-8",

language = "English",

volume = "52",

pages = "1496--1516",

journal = "Experimental and Molecular Medicine",

issn = "1226-3613",

publisher = "Korean Society of Med. Biochemistry and Mol. Biology",

number = "9",

}

TY - JOUR

T1 - Glutamine reliance in cell metabolism

AU - Yoo, Hee Chan

AU - Yu, Ya Chun

AU - Sung, Yulseung

AU - Han, Jung Min

N1 - Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2018R1A6A1A03023718 and 2020R1I1A1A01067423) and by the NRF grant funded by the Korean government (MSIT) (2020M3E5E2040282). H.C.Y. was supported by the Graduate School of Yonsei University Research Scholarship Grants in 2019. Publisher Copyright: © 2020, The Author(s).

PY - 2020/9/1

Y1 - 2020/9/1

N2 - As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer.

AB - As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer.

UR - http://www.scopus.com/inward/record.url?scp=85091178608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85091178608&partnerID=8YFLogxK

U2 - 10.1038/s12276-020-00504-8

DO - 10.1038/s12276-020-00504-8

M3 - Review article

C2 - 32943735

AN - SCOPUS:85091178608

VL - 52

SP - 1496

EP - 1516

JO - Experimental and Molecular Medicine

JF - Experimental and Molecular Medicine

SN - 1226-3613

IS - 9

ER -

Glutamine reliance in cell metabolism

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this