Glycoconjugate nanoribbons from the self-assembly of carbohydrate - Peptide block molecules for controllable bacterial cell cluster formation

Yong Beom Lim, Somi Park, Eunji Lee, Haemi Jeong, Ja Hyoung Ryu, Myeong Sup Lee, Myongsoo Lee

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We demonstrate here the rational design strategy to control the length of 1-dimensional β-sheet peptide nanoassembly. We synthesized the β-sheet peptides with attached coils and carbohydrates. We reasoned that the bulkiness of the coils affects the final length of the assembled β-sheet peptide nanostructures because of the steric crowding effect. The nanostructure from the peptide with a small and linear coil was several micrometers long, whereas the one from the peptide with a high-volume-fraction dendritic coil was only about 150 nm long. For potential biological applications of the peptide nanoassemblies, we investigated the interactions of the carbohydrate-coated nanoassemblies with E. coli cells containing cognate binding proteins. The results showed that both of the nanoassemblies could immobilize and/or aggregate bacterial cells. The degrees of immobilization were similar for both nanoassemblies; however, only the long nanoribbon was shown to induce the formation of bacterial clusters.

Original languageEnglish
Pages (from-to)1404-1408
Number of pages5
JournalBiomacromolecules
Volume8
Issue number5
DOIs
Publication statusPublished - 2007 May 1

Fingerprint

Nanoribbons
Carbon Nanotubes
Glycoconjugates
Carbohydrates
Self assembly
Peptides
Molecules
Nanostructures
Escherichia coli
Volume fraction
Carrier Proteins

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Lim, Yong Beom ; Park, Somi ; Lee, Eunji ; Jeong, Haemi ; Ryu, Ja Hyoung ; Lee, Myeong Sup ; Lee, Myongsoo. / Glycoconjugate nanoribbons from the self-assembly of carbohydrate - Peptide block molecules for controllable bacterial cell cluster formation. In: Biomacromolecules. 2007 ; Vol. 8, No. 5. pp. 1404-1408.
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Glycoconjugate nanoribbons from the self-assembly of carbohydrate - Peptide block molecules for controllable bacterial cell cluster formation. / Lim, Yong Beom; Park, Somi; Lee, Eunji; Jeong, Haemi; Ryu, Ja Hyoung; Lee, Myeong Sup; Lee, Myongsoo.

In: Biomacromolecules, Vol. 8, No. 5, 01.05.2007, p. 1404-1408.

Research output: Contribution to journalArticle

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