Glycolysis on f-18 fdg pet/ct is superior to amino acid metabolism on c-11 methionine pet/ct in identifying advanced renal cell carcinoma at staging

Suk Hyun Lee, Jee Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung Hwan Lee, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Mijin Yun

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the value of F-18 fluorodeoxyglucose (FDG) and C-11 methionine positron emission tomography/computed tomography (PET/CT) to predict high-Fuhrman grade and advanced-stage tumours in patients with renal cell carcinoma (RCC). Forty patients with RCC underwent F-18 FDG and C-11 methionine PET/CT between September 2016 and September 2018. They were classified into limited (stages I and II, n = 15) or advanced stages (stages III and IV, n = 25) according to pathological staging. Logistic regressions were used to predict the advanced stage using various parameters, including maximum standardised uptake value (SUVmax) and metabolic tumour volume (MTV). Receiver operating characteristic analyses were performed to predict highgrade tumours (Fuhrman 3 and 4). On univariate analysis, tumour size, SUVmax and MTV of F-18 FDG and C-11 methionine, and Fuhrman grades were significant predictors for the advanced stage. On multivariate analysis, F-18 FDG MTV > 21.3 cm3 was the most significant predictor (p < 0.001). The area under the curve for predicting high-grade tumours was 0.830 for F-18 FDG (p < 0.001) and 0.726 for C-11 methionine PET/CT (p = 0.014). In conclusion, glycolysis on F-18 FDG PET/CT and amino acid metabolism on C-11 methionine PET/CT were variable but increased in high-grade RCCs. Increased MTV on F-18 FDG PET/CT is a powerful predictor of advanced-stage tumours.

Original languageEnglish
Article number2381
JournalCancers
Volume13
Issue number10
DOIs
Publication statusPublished - 2021 May 2

Bibliographical note

Funding Information:
Funding: This research was supported by the “Conditional Approval System of Health Technology”, funded by the Ministry of Health and Welfare and the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (NRF-2020R1A2B5B01098109).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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