Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

Jinyoung Kang, Jaemoon Yang, Jaewon Lee, Seung Jae Oh, Seyoung Moon, Hong Jae Lee, Sang Cheon Lee, Joo Hiuk Son, Donghyun Kim, Kwangyeol Lee, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

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Abstract

We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux ® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

Original languageEnglish
Pages (from-to)2902-2905
Number of pages4
JournalJournal of Materials Chemistry
Volume19
Issue number19
DOIs
Publication statusPublished - 2009 May 18

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Chemistry

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