Gold nanoislands chip for laser desorption/ionization (LDI) mass spectrometry

Joo Yoon Noh, Jo Il Kim, Young Wook Chang, Jong Min Park, Hyun Woo Song, Min Jung Kang, Jae Chul Pyun

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Abstract

Gold nanoislands chip were developed as a solid matrix for the analysis of small molecules using laser desorption/ionization time-of-flight (LDIToF) mass spectrometry substituting the organic matrices which usually produce strong noise at low massto- charge ratio range (m/z<500). Gold nanoislands were simply prepared by (1) deposition of gold layer on highly P-doped silicon substrate followed by (2) heating. Physical properties of the gold nanoislands were analyzed by scanning electron microscope (SEM), atomic force microscopy (AFM) analysis to characterize the morphology, diameter, thickness, and surface density of the nanoislands which were comparatively analyzed in conjunction with LDI-ToF mass spectrometry. In this work, optimal size of the nanoislands were selected for LDI-ToF mass spectrometry, and gold nanoislands chip were applied to the quantitative and simultaneous detection of small analytes (amino acids) with various chemical and physical properties (polar, nonpolar, acidic, and basic).

Original languageEnglish
Pages (from-to)246-254
Number of pages9
JournalBiochip Journal
Volume11
Issue number3
DOIs
Publication statusPublished - 2017 Sep 1

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Noh, J. Y., Kim, J. I., Chang, Y. W., Park, J. M., Song, H. W., Kang, M. J., & Pyun, J. C. (2017). Gold nanoislands chip for laser desorption/ionization (LDI) mass spectrometry. Biochip Journal, 11(3), 246-254. https://doi.org/10.1007/s13206-017-1310-0