Gold-nanoparticle-coated magnetic beads for concentration and ionization of analytes for laser desorption/ionization mass spectrometry

Moon Ju Kim, Jong Min Park, Joo Yoon Noh, Tae Gyeong Yun, Min Jung Kang, Jae Chul Pyun

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rationale: Magnetic particles coated with gold nanoparticles (Au NPs) (Au-MAGs) were developed and used (1) for sample concentration and (2) as a solid matrix for laser adsorption/desorption mass spectrometry (LDI-MS). Methods: The Au-MAGs were prepared by (1) coating polystyrene on iron oxide NPs (PS-MNPs), (2) coating poly-l-lysine on the PS-MNPs (PLL-coated PS-MNPs), and (3) coating negatively charged Au NPs on the PLL-coated PS-MNPs (Au-MAGs). Results: The Au-MAGs were used to concentrate the target analyte by means of electrostatic interactions between the positively charged GHP9 and the negatively charged Au-MAGs as well as selective interactions (such as gold–sulfur interactions) between glutathione (GSH) and Au-MAGs. Then, the concentrated analyte could be ionized for LDI-MS. Conclusions: The Au-MAGs were demonstrated (1) to concentrate the target analyte in a sample solution, tested by electrostatic interactions and selective interactions between gold and sulfur and (2) to ionize the concentrated analyte for LDI-MS.

Original languageEnglish
Pages (from-to)527-538
Number of pages12
JournalRapid Communications in Mass Spectrometry
Volume33
Issue number5
DOIs
Publication statusPublished - 2019 Mar 15

Fingerprint

Gold
Ionization
Mass spectrometry
Desorption
Phase locked loops
Nanoparticles
Coulomb interactions
Adsorption
Coatings
Lasers
Polystyrenes
Sulfur
Lysine
Glutathione
ferric oxide
tert-nitrosobutane

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

Cite this

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title = "Gold-nanoparticle-coated magnetic beads for concentration and ionization of analytes for laser desorption/ionization mass spectrometry",
abstract = "Rationale: Magnetic particles coated with gold nanoparticles (Au NPs) (Au-MAGs) were developed and used (1) for sample concentration and (2) as a solid matrix for laser adsorption/desorption mass spectrometry (LDI-MS). Methods: The Au-MAGs were prepared by (1) coating polystyrene on iron oxide NPs (PS-MNPs), (2) coating poly-l-lysine on the PS-MNPs (PLL-coated PS-MNPs), and (3) coating negatively charged Au NPs on the PLL-coated PS-MNPs (Au-MAGs). Results: The Au-MAGs were used to concentrate the target analyte by means of electrostatic interactions between the positively charged GHP9 and the negatively charged Au-MAGs as well as selective interactions (such as gold–sulfur interactions) between glutathione (GSH) and Au-MAGs. Then, the concentrated analyte could be ionized for LDI-MS. Conclusions: The Au-MAGs were demonstrated (1) to concentrate the target analyte in a sample solution, tested by electrostatic interactions and selective interactions between gold and sulfur and (2) to ionize the concentrated analyte for LDI-MS.",
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Gold-nanoparticle-coated magnetic beads for concentration and ionization of analytes for laser desorption/ionization mass spectrometry. / Kim, Moon Ju; Park, Jong Min; Noh, Joo Yoon; Yun, Tae Gyeong; Kang, Min Jung; Pyun, Jae Chul.

In: Rapid Communications in Mass Spectrometry, Vol. 33, No. 5, 15.03.2019, p. 527-538.

Research output: Contribution to journalArticle

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T1 - Gold-nanoparticle-coated magnetic beads for concentration and ionization of analytes for laser desorption/ionization mass spectrometry

AU - Kim, Moon Ju

AU - Park, Jong Min

AU - Noh, Joo Yoon

AU - Yun, Tae Gyeong

AU - Kang, Min Jung

AU - Pyun, Jae Chul

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AB - Rationale: Magnetic particles coated with gold nanoparticles (Au NPs) (Au-MAGs) were developed and used (1) for sample concentration and (2) as a solid matrix for laser adsorption/desorption mass spectrometry (LDI-MS). Methods: The Au-MAGs were prepared by (1) coating polystyrene on iron oxide NPs (PS-MNPs), (2) coating poly-l-lysine on the PS-MNPs (PLL-coated PS-MNPs), and (3) coating negatively charged Au NPs on the PLL-coated PS-MNPs (Au-MAGs). Results: The Au-MAGs were used to concentrate the target analyte by means of electrostatic interactions between the positively charged GHP9 and the negatively charged Au-MAGs as well as selective interactions (such as gold–sulfur interactions) between glutathione (GSH) and Au-MAGs. Then, the concentrated analyte could be ionized for LDI-MS. Conclusions: The Au-MAGs were demonstrated (1) to concentrate the target analyte in a sample solution, tested by electrostatic interactions and selective interactions between gold and sulfur and (2) to ionize the concentrated analyte for LDI-MS.

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