Abstract
Viruses are infectious agents that pose significant threats to plants, animals, and humans. The current coronavirus disease 2019 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally and resulted in over 2 million deaths and immeasurable financial losses. Rapid and sensitive virus diagnostics become crucially important in controlling the spread of a pandemic before effective treatment and vaccines are available. Gold nanoparticle (AuNP)-based testing holds great potential for this urgent unmet biomedical need. In this review, we describe the most recent advances in AuNP-based viral detection applications. In addition, we discuss considerations for the design of AuNP-based SARS-CoV-2 testings. Finally, we highlight and propose important parameters to consider for the future development of effective AuNP-based testings that would be critical for not only this COVID-19 pandemic, but also potential future outbreaks. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing.
| Original language | English |
|---|---|
| Article number | e1754 |
| Journal | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2022 Jan 1 |
Bibliographical note
Funding Information:National Institutes of Health (NIH), Grant/Award Numbers: RF1AG052324, R01DK071801; Division of Materials Research, Grant/Award Number: 1808251; UW‐Madison School of Pharmacy; Wisconsin Alumni Research Foundation; Milton J. Henrichs Chair Professorship; National Science Foundation, Grant/Award Number: DMR‐1808251; Wisconsin Center for NanoBioSystems Funding information
Funding Information:
This work has been partially supported by the funds of the Wisconsin Center for NanoBioSystems, provided from the School of Pharmacy and UW Institute for Clinical and Translational Research (ICTR) of the University of Wisconsin‐Madison (UW‐Madison). S.H. acknowledges financial support from National Science Foundation (grant # DMR‐1808251) and Milton J. Henrichs Chair Professorship. L.L. acknowledges financial support by the National Institutes of Health (NIH) grants RF1AG052324 and R01DK071801, and a Vilas Distinguished Achievement Professorship and Charles Melbourne Johnson Distinguished Chair Professorship with funding provided by the Wisconsin Alumni Research Foundation and UW‐Madison School of Pharmacy.
Funding Information:
This work has been partially supported by the funds of the Wisconsin Center for NanoBioSystems, provided from the School of Pharmacy and UW Institute for Clinical and Translational Research (ICTR) of the University of Wisconsin-Madison (UW-Madison). S.H. acknowledges financial support from National Science Foundation (grant # DMR-1808251) and Milton J. Henrichs Chair Professorship. L.L. acknowledges financial support by the National Institutes of Health (NIH) grants RF1AG052324 and R01DK071801, and a Vilas Distinguished Achievement Professorship and Charles Melbourne Johnson Distinguished Chair Professorship with funding provided by the Wisconsin Alumni Research Foundation and UW-Madison School of Pharmacy.
Publisher Copyright:
© 2021 Wiley Periodicals LLC.
All Science Journal Classification (ASJC) codes
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
