Golgi polarization plays a role in the directional migration of neonatal dermal fibroblasts induced by the direct current electric fields

Min Sung Kim, Mi Hee Lee, Byeong Ju Kwon, Min Ah Koo, Gyeung Mi Seon, Jong Chul Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Directional cell migration requires cell polarization. The reorganization of the Golgi apparatus is an important phenomenon in the polarization and migration of many types of cells. Direct current electric fields (dc (EF) induced directional cell migration in a wide variety of cells. Here nHDFs migrated toward cathode under 1 V/cm dc EF, however 1 μM of brefeldin A (BFA) inhibited the dc EF induced directional migration. BFA (1 μM) did not cause the complete Golgi dispersal for 2 h. When the Golgi polarization maintained their direction of polarity, the direction of cell migration also kept toward the same direction of the Golgi polarization even though the dc EF was reversed. In this study, the importance of the Golgi polarization in the directional migration of nHDf under dc EF was identified.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume460
Issue number2
DOIs
Publication statusPublished - 2015 May 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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