Good responders to catheter ablation for long-standing persistent atrial fibrillation: Clinical and genetic characteristics

Jin Kyu Park, Ji Young Lee, Pil Sung Yang, Tae Hoon Kim, Eunsoon Shin, Junbeom Park, Jae Sun Uhm, Boyoung Joung, Moon Hyoung Lee, Hui Nam Pak

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Abstract

Background Radiofrequency catheter ablation (RFCA) for long-standing persistent atrial fibrillation (L-PeAF) is challenging and has a relatively high recurrence rate. We explored clinical and genetic characteristics associated with being good responders (no early or clinical recurrence within 12 months in the absence of anti-arrhythmic drugs) to RFCA among patients with L-PeAF. Methods Of 1319 patients in the Yonsei AF Ablation Cohort, this study included 141 consecutive patients with L-PeAF (80.9% male, age 57.8 ± 9.7 years) who were followed >12 months after RFCA. Results During 25 (19–35) months follow-up, the recurrence rate was 39%, and 38 patients (27%) were categorized as good responders, those had a shorter AF duration (p = 0.010), and smaller left atrial (LA) size (p = 0.033) than others. The rs2106216 (16q22/ZFHX3) genetic polymorphism was independently associated with being a good responder in multivariate analysis (adjusted OR = 2.70, 95% CI 1.41–5.14, p = 0.003), after adjusting for LA size and AF duration. The rs2106261 had predictive value for clinical recurrence of AF after RFCA among patients with an AF duration 12–65 months (log rank, p = 0.025). Conclusions Despite a relatively high recurrence rate after RFCA for L-PeAF, patients with a shorter AF duration and smaller LA size showed a more favorable outcome. The rs2106216 polymorphism (ZFHX3) was independently associated with being good responders to RFCA for L-PeAF, especially with AF duration 12–65 months.

Original languageEnglish
Pages (from-to)584-590
Number of pages7
JournalJournal of Cardiology
Volume69
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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