Graphene-electrode array for brain map remodeling of the cortical surface

Minseok Lee; Sangwon Lee; Jejung Kim; Jeongsik Lim; Jinho Lee; Samer Masri; Shaowen Bao; Sunggu Yang; Jong Hyun Ahn; Sungchil Yang

doi:10.1038/s41427-021-00334-8

Graphene-electrode array for brain map remodeling of the cortical surface

Minseok Lee, Sangwon Lee, Jejung Kim, Jeongsik Lim, Jinho Lee, Samer Masri, Shaowen Bao, Sunggu Yang, Jong Hyun Ahn, Sungchil Yang

Department of Electrical and Electronic Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Cortical maps, which are indicative of cognitive status, are shaped by the organism’s experience. Previous mapping tools, such as penetrating electrodes and imaging techniques, are limited in their ability to be used to assess high-resolution brain maps largely owing to their invasiveness and poor spatiotemporal resolution, respectively. In this study, we developed a flexible graphene-based multichannel electrode array for electrocorticography (ECoG) recording, which enabled us to assess cortical maps in a time- and labor-efficient manner. The flexible electrode array, formed by chemical vapor deposition (CVD)-grown graphene, provided low impedance and electrical noise because a good interface between the graphene and brain tissue was created, which improved the detectability of neural signals. Furthermore, cortical map remodeling was induced upon electrical stimulation at the cortical surface through a subset of graphene spots. This result demonstrated the macroscale plasticity of cortical maps, suggesting perceptual enhancement via electrical rehabilitation at the cortical surface.

Original language	English
Article number	65
Journal	NPG Asia Materials
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41427-021-00334-8
Publication status	Published - 2021 Dec

Bibliographical note

Funding Information:
This work was supported by the Technology Innovation Program (20012355, fully implantable closed-loop Brain to X for voice communication) funded by MOTIE, Korea and High Risk, High Return Research Program (2020) in the Incheon National University for Sunggu Yang and the National Research Foundation of Korea (NRF-2015R1A3A2066337) for J.-H Ahn. Sungchil Yang acknowledged grants from the Research Grants Council of Hong Kong (11102120 and 11102618).

Publisher Copyright:
© 2021, The Author(s).

All Science Journal Classification (ASJC) codes

Modelling and Simulation
Materials Science(all)
Condensed Matter Physics

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10.1038/s41427-021-00334-8

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abstract = "Cortical maps, which are indicative of cognitive status, are shaped by the organism{\textquoteright}s experience. Previous mapping tools, such as penetrating electrodes and imaging techniques, are limited in their ability to be used to assess high-resolution brain maps largely owing to their invasiveness and poor spatiotemporal resolution, respectively. In this study, we developed a flexible graphene-based multichannel electrode array for electrocorticography (ECoG) recording, which enabled us to assess cortical maps in a time- and labor-efficient manner. The flexible electrode array, formed by chemical vapor deposition (CVD)-grown graphene, provided low impedance and electrical noise because a good interface between the graphene and brain tissue was created, which improved the detectability of neural signals. Furthermore, cortical map remodeling was induced upon electrical stimulation at the cortical surface through a subset of graphene spots. This result demonstrated the macroscale plasticity of cortical maps, suggesting perceptual enhancement via electrical rehabilitation at the cortical surface.",

author = "Minseok Lee and Sangwon Lee and Jejung Kim and Jeongsik Lim and Jinho Lee and Samer Masri and Shaowen Bao and Sunggu Yang and Ahn, {Jong Hyun} and Sungchil Yang",

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AU - Masri, Samer

AU - Bao, Shaowen

AU - Yang, Sunggu

AU - Ahn, Jong Hyun

AU - Yang, Sungchil

N1 - Funding Information: This work was supported by the Technology Innovation Program (20012355, fully implantable closed-loop Brain to X for voice communication) funded by MOTIE, Korea and High Risk, High Return Research Program (2020) in the Incheon National University for Sunggu Yang and the National Research Foundation of Korea (NRF-2015R1A3A2066337) for J.-H Ahn. Sungchil Yang acknowledged grants from the Research Grants Council of Hong Kong (11102120 and 11102618). Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Cortical maps, which are indicative of cognitive status, are shaped by the organism’s experience. Previous mapping tools, such as penetrating electrodes and imaging techniques, are limited in their ability to be used to assess high-resolution brain maps largely owing to their invasiveness and poor spatiotemporal resolution, respectively. In this study, we developed a flexible graphene-based multichannel electrode array for electrocorticography (ECoG) recording, which enabled us to assess cortical maps in a time- and labor-efficient manner. The flexible electrode array, formed by chemical vapor deposition (CVD)-grown graphene, provided low impedance and electrical noise because a good interface between the graphene and brain tissue was created, which improved the detectability of neural signals. Furthermore, cortical map remodeling was induced upon electrical stimulation at the cortical surface through a subset of graphene spots. This result demonstrated the macroscale plasticity of cortical maps, suggesting perceptual enhancement via electrical rehabilitation at the cortical surface.

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Graphene-electrode array for brain map remodeling of the cortical surface

Abstract

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