Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells

Tapas R. Nayak, Henrik Andersen, Venkata S. Makam, Clement Khaw, Sukang Bae, Xiangfan Xu, Pui Lai R. Ee, Jong Hyun Ahn, Byung Hee Hong, Giorgia Pastorin, Barbaros Özyilmaz

Research output: Contribution to journalArticle

551 Citations (Scopus)

Abstract

Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphenes potential for stem cell research.

Original languageEnglish
Pages (from-to)4670-4678
Number of pages9
JournalACS Nano
Volume5
Issue number6
DOIs
Publication statusPublished - 2011 Jun 28

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Graphite
stem cells
Stem cells
Graphene
graphene
bones
Bone
Intercellular Signaling Peptides and Proteins
transplantation
cartilage
tissue engineering
Cell proliferation
Cartilage
Scaffolds (biology)
muscles
regeneration
Tissue engineering
Scaffolds
Muscle
therapy

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Nayak, T. R., Andersen, H., Makam, V. S., Khaw, C., Bae, S., Xu, X., ... Özyilmaz, B. (2011). Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano, 5(6), 4670-4678. https://doi.org/10.1021/nn200500h
Nayak, Tapas R. ; Andersen, Henrik ; Makam, Venkata S. ; Khaw, Clement ; Bae, Sukang ; Xu, Xiangfan ; Ee, Pui Lai R. ; Ahn, Jong Hyun ; Hong, Byung Hee ; Pastorin, Giorgia ; Özyilmaz, Barbaros. / Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. In: ACS Nano. 2011 ; Vol. 5, No. 6. pp. 4670-4678.
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Nayak, TR, Andersen, H, Makam, VS, Khaw, C, Bae, S, Xu, X, Ee, PLR, Ahn, JH, Hong, BH, Pastorin, G & Özyilmaz, B 2011, 'Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells', ACS Nano, vol. 5, no. 6, pp. 4670-4678. https://doi.org/10.1021/nn200500h

Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. / Nayak, Tapas R.; Andersen, Henrik; Makam, Venkata S.; Khaw, Clement; Bae, Sukang; Xu, Xiangfan; Ee, Pui Lai R.; Ahn, Jong Hyun; Hong, Byung Hee; Pastorin, Giorgia; Özyilmaz, Barbaros.

In: ACS Nano, Vol. 5, No. 6, 28.06.2011, p. 4670-4678.

Research output: Contribution to journalArticle

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