Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells

Nur Farhanah Rosli, Michaela Fojtů, Adrian C. Fisher, Martin Pumera

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Graphene oxide (GO) has been widely explored by many in drug delivery strategies and toxicity assays. The toxicity of graphene oxide depends on the size of the sheets. Smaller sheets show lower toxicity, a quality which is essential for utilization in biomedical applications. However, despite vast research on GO, anticancer properties and drug carrier capabilities of graphene oxide nanoplatelets have yet to be fully explored. Herein, we have uniquely prepared graphene oxide nanoplatelets (GONPs) from well-defined stacked graphite nanofibers (SGNF) with a base of 50 × 50 nm 2 for toxicity and drug potentiation studies when coadministered with the chemotherapeutic drug cisplatin (CP) in human lung cancer cells, A549 cells. Results obtained from our studies have found that not only were GONPs able to act as drug carriers, but they can also significantly potentiate anticancer effect of CP in A549 cells.

Original languageEnglish
Pages (from-to)3176-3182
Number of pages7
Issue number8
Publication statusPublished - 2019 Feb 26

Bibliographical note

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). Authors thank the A*Star grant (No. SERC A1783c0005), Singapore. This research is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its CREATE programme. This work was supported by Grant Agency of the Czech Republic (GACR - 18-24089S).

Publisher Copyright:
© 2019 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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