Green synthesis and biological evaluation of new Di-α- aminophosphonate derivatives as cytotoxic agents

Kunda Uma Maheswara Rao, Sim Namkoong, Hwan Chul Yu, Junsoo Park, Chan Moon Chung, Se Young Oh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H2O under ultrasonic irradiation and were characterized by IR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity. Novel di-α-aminophosphonate derivatives were synthesized by a one-pot method and evaluated for their cytotoxic activity against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7. All compounds showed moderate cytotoxic activity on both cell lines; compounds 4b and 4c showed marked activity.

Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalArchiv der Pharmazie
Volume346
Issue number12
DOIs
Publication statusPublished - 2013 Dec

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

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