Green synthesis and biological evaluation of new Di-α- aminophosphonate derivatives as cytotoxic agents

Kunda Uma Maheswara Rao; Sim Namkoong; Hwan Chul Yu; Junsoo Park; Chan Moon Chung; Se Young Oh

doi:10.1002/ardp.201300249

Green synthesis and biological evaluation of new Di-α- aminophosphonate derivatives as cytotoxic agents

Kunda Uma Maheswara Rao, Sim Namkoong, Hwan Chul Yu, Junsoo Park, Chan Moon Chung, Se Young Oh

Division of Bioscience and Biotechnology

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H₂O under ultrasonic irradiation and were characterized by IR, ¹H NMR, ¹³C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity. Novel di-α-aminophosphonate derivatives were synthesized by a one-pot method and evaluated for their cytotoxic activity against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7. All compounds showed moderate cytotoxic activity on both cell lines; compounds 4b and 4c showed marked activity.

Original language	English
Pages (from-to)	851-859
Number of pages	9
Journal	Archiv der Pharmazie
Volume	346
Issue number	12
DOIs	https://doi.org/10.1002/ardp.201300249
Publication status	Published - 2013 Dec

All Science Journal Classification (ASJC) codes

Pharmaceutical Science
Drug Discovery

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Uma Maheswara Rao, K., Namkoong, S., Yu, H. C., Park, J., Chung, C. M., & Oh, S. Y. (2013). Green synthesis and biological evaluation of new Di-α- aminophosphonate derivatives as cytotoxic agents. Archiv der Pharmazie, 346(12), 851-859. https://doi.org/10.1002/ardp.201300249

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title = "Green synthesis and biological evaluation of new Di-α- aminophosphonate derivatives as cytotoxic agents",

abstract = "A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H2O under ultrasonic irradiation and were characterized by IR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity. Novel di-α-aminophosphonate derivatives were synthesized by a one-pot method and evaluated for their cytotoxic activity against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7. All compounds showed moderate cytotoxic activity on both cell lines; compounds 4b and 4c showed marked activity.",

author = "{Uma Maheswara Rao}, Kunda and Sim Namkoong and Yu, {Hwan Chul} and Junsoo Park and Chung, {Chan Moon} and Oh, {Se Young}",

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AU - Chung, Chan Moon

AU - Oh, Se Young

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