Abstract
A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H2O under ultrasonic irradiation and were characterized by IR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity. Novel di-α-aminophosphonate derivatives were synthesized by a one-pot method and evaluated for their cytotoxic activity against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7. All compounds showed moderate cytotoxic activity on both cell lines; compounds 4b and 4c showed marked activity.
| Original language | English |
|---|---|
| Pages (from-to) | 851-859 |
| Number of pages | 9 |
| Journal | Archiv der Pharmazie |
| Volume | 346 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2013 Dec 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery
Cite this
}
Green synthesis and biological evaluation of new Di-α- aminophosphonate derivatives as cytotoxic agents. / Uma Maheswara Rao, Kunda; Namkoong, Sim; Yu, Hwan Chul; Park, Junsoo; Chung, Chan Moon; Oh, Se Young.
In: Archiv der Pharmazie, Vol. 346, No. 12, 01.12.2013, p. 851-859.Research output: Contribution to journal › Article
TY - JOUR
T1 - Green synthesis and biological evaluation of new Di-α- aminophosphonate derivatives as cytotoxic agents
AU - Uma Maheswara Rao, Kunda
AU - Namkoong, Sim
AU - Yu, Hwan Chul
AU - Park, Junsoo
AU - Chung, Chan Moon
AU - Oh, Se Young
PY - 2013/12/1
Y1 - 2013/12/1
N2 - A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H2O under ultrasonic irradiation and were characterized by IR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity. Novel di-α-aminophosphonate derivatives were synthesized by a one-pot method and evaluated for their cytotoxic activity against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7. All compounds showed moderate cytotoxic activity on both cell lines; compounds 4b and 4c showed marked activity.
AB - A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H2O under ultrasonic irradiation and were characterized by IR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity. Novel di-α-aminophosphonate derivatives were synthesized by a one-pot method and evaluated for their cytotoxic activity against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7. All compounds showed moderate cytotoxic activity on both cell lines; compounds 4b and 4c showed marked activity.
UR - http://www.scopus.com/inward/record.url?scp=84889643308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84889643308&partnerID=8YFLogxK
U2 - 10.1002/ardp.201300249
DO - 10.1002/ardp.201300249
M3 - Article
C2 - 24214666
AN - SCOPUS:84889643308
VL - 346
SP - 851
EP - 859
JO - Archiv der Pharmazie
JF - Archiv der Pharmazie
SN - 0365-6233
IS - 12
ER -