Grey matter abnormalities in obsessive-compulsive disorder: Statistical parametric mapping of segmented magnetic resonance images

J. Kim, Chul Lee Myung Chul Lee, J. Kim, Young Kim In Young Kim, S. I. Kim, Hee Han Moon Hee Han, K. Chang, Soo Kwon Jun Soo Kwon

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Abstract

Background Although anumber of functional imaging studies are in agreement in suggesting orbitofrontal and subcortical hyperfunction in the pathophysiology of obsessive-compulsive disorder (OCD), the structural findings have been contradictory. Aims To investigate grey matter abnormalities in patients with OCD by employing a novel voxel-based analysis of magnetic resonance images. Method Statistical parametric mapping was utilised to compare segmented grey matter images from 25 patients with OCD with those from 25 matched controls. Results Increased regional grey matter density was found in multiple cortical areas, including the left orbitofrontal cortex, and in subcortical areas, including the thalamus. On the other hand, regions of reduction were confined to posterior parts of the brain, such as the left cuneus and the left cerebellum. Conclusions Increased grey matter density of frontal - subcortical circuits, consonant with the hypermetabolic findings from functional imaging studies, seems to exist in patients with OCD, and cerebellar dysfunction may be involved in the pathophysiology of OCD.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalBritish Journal of Psychiatry
Volume179
Issue numberOCT.
DOIs
Publication statusPublished - 2001 Nov 6

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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    Kim, J., Myung Chul Lee, C. L., Kim, J., In Young Kim, Y. K., Kim, S. I., Moon Hee Han, H. H., Chang, K., & Jun Soo Kwon, S. K. (2001). Grey matter abnormalities in obsessive-compulsive disorder: Statistical parametric mapping of segmented magnetic resonance images. British Journal of Psychiatry, 179(OCT.), 330-334. https://doi.org/10.1192/bjp.179.4.330