Group 6 Layered Transition-Metal Dichalcogenides in Lab-on-a-Chip Devices: 1T-Phase WS2 for Microfluidics Non-Enzymatic Detection of Hydrogen Peroxide

Rou Jun Toh; Carmen C. Mayorga-Martinez; Jongyoon Han; Zdenek Sofer; Martin Pumera

doi:10.1021/acs.analchem.7b00302

Group 6 Layered Transition-Metal Dichalcogenides in Lab-on-a-Chip Devices: 1T-Phase WS₂ for Microfluidics Non-Enzymatic Detection of Hydrogen Peroxide

Rou Jun Toh, Carmen C. Mayorga-Martinez, Jongyoon Han, Zdenek Sofer, Martin Pumera

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS₂, MoSe₂, WS₂, and WSe₂) within the LOC devices by the drop-casting method and compared their performance for H₂O₂ detection. The 1T-phase WS₂-based LOC device outperformed the rest of the TMD materials and exhibited a wide range of linear response (20 nM to 20 μM and 100 μM to 2 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis. This work may facilitate the expanded use of electrochemical LOC microfluidics, with its easier integrability, for applications in the field of biodiagnostics and sensing.

Original language	English
Pages (from-to)	4978-4985
Number of pages	8
Journal	Analytical Chemistry
Volume	89
Issue number	9
DOIs	https://doi.org/10.1021/acs.analchem.7b00302
Publication status	Published - 2017 May 2

Bibliographical note

Funding Information:
M.P. acknowledges a Tier 2 grant (MOE2013-T2-1-056; ARC 35/13) from the Ministry of Education, Singapore. R.J.T. and J.H. were also supported by the research grant for the Singapore-MIT Alliance for Research and Technology (SMART) centre (BioSyM IRG), funded by the National Research Foundation (NRF) of Singapore. Z.S was supported by the Czech Science Foundation (GACR No. 16-05167S).

Publisher Copyright:
© 2017 American Chemical Society.

All Science Journal Classification (ASJC) codes

Analytical Chemistry

Access to Document

10.1021/acs.analchem.7b00302

Cite this

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title = "Group 6 Layered Transition-Metal Dichalcogenides in Lab-on-a-Chip Devices: 1T-Phase WS2 for Microfluidics Non-Enzymatic Detection of Hydrogen Peroxide",

abstract = "Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS2, MoSe2, WS2, and WSe2) within the LOC devices by the drop-casting method and compared their performance for H2O2 detection. The 1T-phase WS2-based LOC device outperformed the rest of the TMD materials and exhibited a wide range of linear response (20 nM to 20 μM and 100 μM to 2 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis. This work may facilitate the expanded use of electrochemical LOC microfluidics, with its easier integrability, for applications in the field of biodiagnostics and sensing.",

author = "Toh, {Rou Jun} and Mayorga-Martinez, {Carmen C.} and Jongyoon Han and Zdenek Sofer and Martin Pumera",

note = "Funding Information: M.P. acknowledges a Tier 2 grant (MOE2013-T2-1-056; ARC 35/13) from the Ministry of Education, Singapore. R.J.T. and J.H. were also supported by the research grant for the Singapore-MIT Alliance for Research and Technology (SMART) centre (BioSyM IRG), funded by the National Research Foundation (NRF) of Singapore. Z.S was supported by the Czech Science Foundation (GACR No. 16-05167S). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

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AU - Han, Jongyoon

AU - Sofer, Zdenek

AU - Pumera, Martin

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N2 - Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS2, MoSe2, WS2, and WSe2) within the LOC devices by the drop-casting method and compared their performance for H2O2 detection. The 1T-phase WS2-based LOC device outperformed the rest of the TMD materials and exhibited a wide range of linear response (20 nM to 20 μM and 100 μM to 2 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis. This work may facilitate the expanded use of electrochemical LOC microfluidics, with its easier integrability, for applications in the field of biodiagnostics and sensing.

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