Abstract
Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS2, MoSe2, WS2, and WSe2) within the LOC devices by the drop-casting method and compared their performance for H2O2 detection. The 1T-phase WS2-based LOC device outperformed the rest of the TMD materials and exhibited a wide range of linear response (20 nM to 20 μM and 100 μM to 2 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis. This work may facilitate the expanded use of electrochemical LOC microfluidics, with its easier integrability, for applications in the field of biodiagnostics and sensing.
| Original language | English |
|---|---|
| Pages (from-to) | 4978-4985 |
| Number of pages | 8 |
| Journal | Analytical Chemistry |
| Volume | 89 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2017 May 2 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
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Group 6 Layered Transition-Metal Dichalcogenides in Lab-on-a-Chip Devices : 1T-Phase WS2 for Microfluidics Non-Enzymatic Detection of Hydrogen Peroxide. / Toh, Rou Jun; Mayorga-Martinez, Carmen C.; Han, Jongyoon; Sofer, Zdenek; Pumera, Martin.
In: Analytical Chemistry, Vol. 89, No. 9, 02.05.2017, p. 4978-4985.Research output: Contribution to journal › Article
TY - JOUR
T1 - Group 6 Layered Transition-Metal Dichalcogenides in Lab-on-a-Chip Devices
T2 - 1T-Phase WS2 for Microfluidics Non-Enzymatic Detection of Hydrogen Peroxide
AU - Toh, Rou Jun
AU - Mayorga-Martinez, Carmen C.
AU - Han, Jongyoon
AU - Sofer, Zdenek
AU - Pumera, Martin
PY - 2017/5/2
Y1 - 2017/5/2
N2 - Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS2, MoSe2, WS2, and WSe2) within the LOC devices by the drop-casting method and compared their performance for H2O2 detection. The 1T-phase WS2-based LOC device outperformed the rest of the TMD materials and exhibited a wide range of linear response (20 nM to 20 μM and 100 μM to 2 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis. This work may facilitate the expanded use of electrochemical LOC microfluidics, with its easier integrability, for applications in the field of biodiagnostics and sensing.
AB - Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS2, MoSe2, WS2, and WSe2) within the LOC devices by the drop-casting method and compared their performance for H2O2 detection. The 1T-phase WS2-based LOC device outperformed the rest of the TMD materials and exhibited a wide range of linear response (20 nM to 20 μM and 100 μM to 2 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis. This work may facilitate the expanded use of electrochemical LOC microfluidics, with its easier integrability, for applications in the field of biodiagnostics and sensing.
UR - http://www.scopus.com/inward/record.url?scp=85020415176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020415176&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.7b00302
DO - 10.1021/acs.analchem.7b00302
M3 - Article
C2 - 28394576
AN - SCOPUS:85020415176
VL - 89
SP - 4978
EP - 4985
JO - Analytical Chemistry
JF - Analytical Chemistry
SN - 0003-2700
IS - 9
ER -