Abstract
Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible.
| Original language | English |
|---|---|
| Pages (from-to) | 626-632 |
| Number of pages | 7 |
| Journal | Oral Diseases |
| Volume | 14 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2008 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
- Dentistry(all)
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Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible. / Kim, J. Y.; Kim, S. T.; Cho, S. W.; Jung, H. S.; Park, K. T.; Son, H. K.
In: Oral Diseases, Vol. 14, No. 7, 01.10.2008, p. 626-632.Research output: Contribution to journal › Article
TY - JOUR
T1 - Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible
AU - Kim, J. Y.
AU - Kim, S. T.
AU - Cho, S. W.
AU - Jung, H. S.
AU - Park, K. T.
AU - Son, H. K.
PY - 2008/10/1
Y1 - 2008/10/1
N2 - Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible.
AB - Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible.
UR - http://www.scopus.com/inward/record.url?scp=53149145069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53149145069&partnerID=8YFLogxK
U2 - 10.1111/j.1601-0825.2007.01435.x
DO - 10.1111/j.1601-0825.2007.01435.x
M3 - Article
C2 - 18331419
AN - SCOPUS:53149145069
VL - 14
SP - 626
EP - 632
JO - Oral Diseases
JF - Oral Diseases
SN - 1354-523X
IS - 7
ER -