Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible

J. Y. Kim, S. T. Kim, S. W. Cho, H. S. Jung, K. T. Park, H. K. Son

Research output: Contribution to journalArticle

24 Citations (Scopus)


Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible.

Original languageEnglish
Pages (from-to)626-632
Number of pages7
JournalOral Diseases
Issue number7
Publication statusPublished - 2008 Oct 1


All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

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