Growth factors as targets in tumor therapy

A. Wellstein, E. B. Sale, Hyuncheol Chung, W. J. Fang, R. V. Smith, K. C. Colley, F. Czubayko

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sustained growth of solid tumors and their metastasis requires paracrine signals between the tumor cells and the normal surrounding host tissue. One crucial function of these signals is to recruit endothelial cells and thus new blood vessels for the nourishment of the expanding tumor mass. In addition, the newly recruited blood vessels serve as routes for metastasis of the primary tumor. The proliferation and migration of endothelial cells in the vicinity of progressing tumors contrasts with a low turn-over rate of endothelial cells in the healthy adult. The only physiologic exception to this rule is the female reproductive cycle. Based on the selective angiogenesis in tumors in contrast to normal tissues, a blockade of this process should be feasible with few adverse effects. We present data on angiogenesis factor gene expression in tumors and discuss different methods of targeting these gene products. Furthermore, we discuss the potential to combine conventional cytotoxic treatments with this new therapeutic approach.

Original languageEnglish
Pages (from-to)35-47
Number of pages13
JournalInternational Journal of Pharmacognosy
Volume33
Issue numberSUPPL.
Publication statusPublished - 1995 Jan 1

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Intercellular Signaling Peptides and Proteins
Neoplasms
Endothelial Cells
Therapeutics
Blood Vessels
Neoplasm Metastasis
Gene Targeting
Angiogenesis Inducing Agents
Gene Expression
Growth

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Wellstein, A., Sale, E. B., Chung, H., Fang, W. J., Smith, R. V., Colley, K. C., & Czubayko, F. (1995). Growth factors as targets in tumor therapy. International Journal of Pharmacognosy, 33(SUPPL.), 35-47.
Wellstein, A. ; Sale, E. B. ; Chung, Hyuncheol ; Fang, W. J. ; Smith, R. V. ; Colley, K. C. ; Czubayko, F. / Growth factors as targets in tumor therapy. In: International Journal of Pharmacognosy. 1995 ; Vol. 33, No. SUPPL. pp. 35-47.
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Wellstein, A, Sale, EB, Chung, H, Fang, WJ, Smith, RV, Colley, KC & Czubayko, F 1995, 'Growth factors as targets in tumor therapy', International Journal of Pharmacognosy, vol. 33, no. SUPPL., pp. 35-47.

Growth factors as targets in tumor therapy. / Wellstein, A.; Sale, E. B.; Chung, Hyuncheol; Fang, W. J.; Smith, R. V.; Colley, K. C.; Czubayko, F.

In: International Journal of Pharmacognosy, Vol. 33, No. SUPPL., 01.01.1995, p. 35-47.

Research output: Contribution to journalArticle

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AU - Wellstein, A.

AU - Sale, E. B.

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AU - Smith, R. V.

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AB - Sustained growth of solid tumors and their metastasis requires paracrine signals between the tumor cells and the normal surrounding host tissue. One crucial function of these signals is to recruit endothelial cells and thus new blood vessels for the nourishment of the expanding tumor mass. In addition, the newly recruited blood vessels serve as routes for metastasis of the primary tumor. The proliferation and migration of endothelial cells in the vicinity of progressing tumors contrasts with a low turn-over rate of endothelial cells in the healthy adult. The only physiologic exception to this rule is the female reproductive cycle. Based on the selective angiogenesis in tumors in contrast to normal tissues, a blockade of this process should be feasible with few adverse effects. We present data on angiogenesis factor gene expression in tumors and discuss different methods of targeting these gene products. Furthermore, we discuss the potential to combine conventional cytotoxic treatments with this new therapeutic approach.

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Wellstein A, Sale EB, Chung H, Fang WJ, Smith RV, Colley KC et al. Growth factors as targets in tumor therapy. International Journal of Pharmacognosy. 1995 Jan 1;33(SUPPL.):35-47.