Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome

Jig Lee Eun Jig Lee, Seok Lee Byung Seok Lee, Chul Lee Hyun Chul Lee, Hyun Park Ki Hyun Park, Ho Song Chan Ho Song, Bum Huh Kap Bum Huh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To evaluate the GH secretion and clarify the factors influencing the GH secretion in women with polycystic ovarian syndrome (PCOS). Design: Comparison of the GH response to L-dopa with or without pyridostigmine (inhibitor of acetylcholinesterase) pretreatment and insulin response to oral glucose tolerance test in patients with PCOS and matched controls. Setting: Outpatients and healthy volunteers studied at a clinical research unit of a university hospital. Patients, Participants: Ten women with PCOS and 9 controls with regular cycles were recruited. Interventions: After an overnight fast, each subject underwent a GH stimulation test with L- dopa with or without pyridostigmine pretreatment. Plasma insulin and glucose levels were measured after a 75-g glucose load. Main Outcome Measures: Plasma GH, insulin-like growth factor I (IGF-I), insulin, and nonesterified fatty acids. Results: Growth hormone responses and GH area under the response curve (AUC) to L-dopa were significantly lower in PCOS than those in controls. Pyridostigmine enhanced the GH response to L-dopa significantly in PCOS. Insulin responses and insulin AUC to oral glucose load were significantly higher in PCOS than those in controls. Plasma IGF-I levels of PCOS were significantly higher than controls. Insulin AUC had a positive correlation with plasma IGF-I levels but an inverse correlation with GH AUC in PCOS and controls. Conclusion: Our result indicated that decreased GH secretion of PCOS may be associated with a high somatostatin activity and a high plasma IGF-I level.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalFertility and Sterility
Volume60
Issue number1
DOIs
Publication statusPublished - 1993

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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    Eun Jig Lee, J. L., Byung Seok Lee, S. L., Hyun Chul Lee, C. L., Ki Hyun Park, H. P., Chan Ho Song, H. S., & Kap Bum Huh, B. H. (1993). Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome. Fertility and Sterility, 60(1), 53-57. https://doi.org/10.1016/s0015-0282(16)56035-x