Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome

Jig Lee Eun Jig Lee, Seok Lee Byung Seok Lee, Chul Lee Hyun Chul Lee, Hyun Park Ki Hyun Park, Ho Song Chan Ho Song, Bum Huh Kap Bum Huh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To evaluate the GH secretion and clarify the factors influencing the GH secretion in women with polycystic ovarian syndrome (PCOS). Design: Comparison of the GH response to L-dopa with or without pyridostigmine (inhibitor of acetylcholinesterase) pretreatment and insulin response to oral glucose tolerance test in patients with PCOS and matched controls. Setting: Outpatients and healthy volunteers studied at a clinical research unit of a university hospital. Patients, Participants: Ten women with PCOS and 9 controls with regular cycles were recruited. Interventions: After an overnight fast, each subject underwent a GH stimulation test with L- dopa with or without pyridostigmine pretreatment. Plasma insulin and glucose levels were measured after a 75-g glucose load. Main Outcome Measures: Plasma GH, insulin-like growth factor I (IGF-I), insulin, and nonesterified fatty acids. Results: Growth hormone responses and GH area under the response curve (AUC) to L-dopa were significantly lower in PCOS than those in controls. Pyridostigmine enhanced the GH response to L-dopa significantly in PCOS. Insulin responses and insulin AUC to oral glucose load were significantly higher in PCOS than those in controls. Plasma IGF-I levels of PCOS were significantly higher than controls. Insulin AUC had a positive correlation with plasma IGF-I levels but an inverse correlation with GH AUC in PCOS and controls. Conclusion: Our result indicated that decreased GH secretion of PCOS may be associated with a high somatostatin activity and a high plasma IGF-I level.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalFertility and Sterility
Volume60
Issue number1
Publication statusPublished - 1993 Jan 1

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Pyridostigmine Bromide
Polycystic Ovary Syndrome
Levodopa
Growth Hormone
Insulin
Insulin-Like Growth Factor I
Area Under Curve
Glucose
Cholinesterase Inhibitors
Glucose Tolerance Test
Somatostatin
Nonesterified Fatty Acids
Healthy Volunteers
Outpatients
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Eun Jig Lee, J. L., Byung Seok Lee, S. L., Hyun Chul Lee, C. L., Ki Hyun Park, H. P., Chan Ho Song, H. S., & Kap Bum Huh, B. H. (1993). Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome. Fertility and Sterility, 60(1), 53-57.
Eun Jig Lee, Jig Lee ; Byung Seok Lee, Seok Lee ; Hyun Chul Lee, Chul Lee ; Ki Hyun Park, Hyun Park ; Chan Ho Song, Ho Song ; Kap Bum Huh, Bum Huh. / Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome. In: Fertility and Sterility. 1993 ; Vol. 60, No. 1. pp. 53-57.
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Eun Jig Lee, JL, Byung Seok Lee, SL, Hyun Chul Lee, CL, Ki Hyun Park, HP, Chan Ho Song, HS & Kap Bum Huh, BH 1993, 'Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome', Fertility and Sterility, vol. 60, no. 1, pp. 53-57.

Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome. / Eun Jig Lee, Jig Lee; Byung Seok Lee, Seok Lee; Hyun Chul Lee, Chul Lee; Ki Hyun Park, Hyun Park; Chan Ho Song, Ho Song; Kap Bum Huh, Bum Huh.

In: Fertility and Sterility, Vol. 60, No. 1, 01.01.1993, p. 53-57.

Research output: Contribution to journalArticle

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Eun Jig Lee JL, Byung Seok Lee SL, Hyun Chul Lee CL, Ki Hyun Park HP, Chan Ho Song HS, Kap Bum Huh BH. Growth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndrome. Fertility and Sterility. 1993 Jan 1;60(1):53-57.