Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

Min Ji An, Jae Hee Cheon, Seung Won Kim, Eun Soo Kim, Tae Il Kim, Won Ho Kim

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalCancer Letters
Volume279
Issue number1
DOIs
Publication statusPublished - 2009 Jun 28

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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