Abstract
This study evaluated the effects of cyanoacrylate-combined calcium phosphate (CCP) as a candidate for a barrier membrane substitute in guided bone regeneration and the space maintenance capability of CCP placed in a dehiscence defect model. Six standardized dehiscence defects (5 × 3 mm, height × width) around dental implants were created on unilateral edentulous ridges in 5 dogs, where each defect was treated with sham surgery, biphasic calcium phosphate (BCP), CCP, barrier membrane (MEM), BCP + MEM, and CCP + MEM. The animals were sacrificed after an 8-week healing interval for histologic and histometric analyses. The BCP and CCP sites showed increased bone formation compared with the control sites, although incomplete defect resolution occurred; bone regeneration heights (area) averaged 3.52 ± 0.69 mm (4.94 ± 2.59 mm2), 3.51 ± 0.16 mm (4.10 ± 1.99 mm2), and 1.53 ± 0.42 mm (1.01 ± 0.74 mm2) for the BCP, CCP, and control sites, respectively. All the MEM sites showed more bone formation compared with the sites that received the same biomaterials without a MEM, and the BCP + MEM and CCP + MEM sites showed extensive bone formation within the defect and on top of the implant; the bone regeneration heights (area) averaged 3.96 ± 2.86 mm (12.46 ± 11.61 mm2), 5.45 ± 0.25 mm (11.63 ± 1.97 mm2), and 2.62 ± 0.27 mm (3.43 ± 0.98 mm2) for the BCP + MEM, CCP + MEM, and MEM sites, respectively. CCP can be a good scaffold for supporting an MEM as opposed to acting as a substitute for the MEM in guided bone regeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 2070-2079 |
| Number of pages | 10 |
| Journal | Journal of Oral and Maxillofacial Surgery |
| Volume | 70 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2012 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology
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Guided bone regeneration using cyanoacrylate-combined calcium phosphate in a dehiscence defect : A histologic study in dogs. / Lee, Jung Seok; Ko, Seung Hee; Kim, Young Taek; Jung, Ui-Won; Choi, Seongho.
In: Journal of Oral and Maxillofacial Surgery, Vol. 70, No. 9, 01.09.2012, p. 2070-2079.Research output: Contribution to journal › Article
TY - JOUR
T1 - Guided bone regeneration using cyanoacrylate-combined calcium phosphate in a dehiscence defect
T2 - A histologic study in dogs
AU - Lee, Jung Seok
AU - Ko, Seung Hee
AU - Kim, Young Taek
AU - Jung, Ui-Won
AU - Choi, Seongho
PY - 2012/9/1
Y1 - 2012/9/1
N2 - This study evaluated the effects of cyanoacrylate-combined calcium phosphate (CCP) as a candidate for a barrier membrane substitute in guided bone regeneration and the space maintenance capability of CCP placed in a dehiscence defect model. Six standardized dehiscence defects (5 × 3 mm, height × width) around dental implants were created on unilateral edentulous ridges in 5 dogs, where each defect was treated with sham surgery, biphasic calcium phosphate (BCP), CCP, barrier membrane (MEM), BCP + MEM, and CCP + MEM. The animals were sacrificed after an 8-week healing interval for histologic and histometric analyses. The BCP and CCP sites showed increased bone formation compared with the control sites, although incomplete defect resolution occurred; bone regeneration heights (area) averaged 3.52 ± 0.69 mm (4.94 ± 2.59 mm2), 3.51 ± 0.16 mm (4.10 ± 1.99 mm2), and 1.53 ± 0.42 mm (1.01 ± 0.74 mm2) for the BCP, CCP, and control sites, respectively. All the MEM sites showed more bone formation compared with the sites that received the same biomaterials without a MEM, and the BCP + MEM and CCP + MEM sites showed extensive bone formation within the defect and on top of the implant; the bone regeneration heights (area) averaged 3.96 ± 2.86 mm (12.46 ± 11.61 mm2), 5.45 ± 0.25 mm (11.63 ± 1.97 mm2), and 2.62 ± 0.27 mm (3.43 ± 0.98 mm2) for the BCP + MEM, CCP + MEM, and MEM sites, respectively. CCP can be a good scaffold for supporting an MEM as opposed to acting as a substitute for the MEM in guided bone regeneration.
AB - This study evaluated the effects of cyanoacrylate-combined calcium phosphate (CCP) as a candidate for a barrier membrane substitute in guided bone regeneration and the space maintenance capability of CCP placed in a dehiscence defect model. Six standardized dehiscence defects (5 × 3 mm, height × width) around dental implants were created on unilateral edentulous ridges in 5 dogs, where each defect was treated with sham surgery, biphasic calcium phosphate (BCP), CCP, barrier membrane (MEM), BCP + MEM, and CCP + MEM. The animals were sacrificed after an 8-week healing interval for histologic and histometric analyses. The BCP and CCP sites showed increased bone formation compared with the control sites, although incomplete defect resolution occurred; bone regeneration heights (area) averaged 3.52 ± 0.69 mm (4.94 ± 2.59 mm2), 3.51 ± 0.16 mm (4.10 ± 1.99 mm2), and 1.53 ± 0.42 mm (1.01 ± 0.74 mm2) for the BCP, CCP, and control sites, respectively. All the MEM sites showed more bone formation compared with the sites that received the same biomaterials without a MEM, and the BCP + MEM and CCP + MEM sites showed extensive bone formation within the defect and on top of the implant; the bone regeneration heights (area) averaged 3.96 ± 2.86 mm (12.46 ± 11.61 mm2), 5.45 ± 0.25 mm (11.63 ± 1.97 mm2), and 2.62 ± 0.27 mm (3.43 ± 0.98 mm2) for the BCP + MEM, CCP + MEM, and MEM sites, respectively. CCP can be a good scaffold for supporting an MEM as opposed to acting as a substitute for the MEM in guided bone regeneration.
UR - http://www.scopus.com/inward/record.url?scp=84865259063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865259063&partnerID=8YFLogxK
U2 - 10.1016/j.joms.2012.04.044
DO - 10.1016/j.joms.2012.04.044
M3 - Article
VL - 70
SP - 2070
EP - 2079
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
SN - 0278-2391
IS - 9
ER -