Guidelines for the next 10 years of proteomics

Marc R. Wilkins, Ron D. Appel, Jennifer E. Van Eyk, Maxey C.M. Chung, Angelika Görg, Michael Hecker, Lukas A. Huber, Hanno Langen, Andrew J. Link, Young-Ki Paik, Scott D. Patterson, Stephen R. Pennington, Thierry Rabilloud, Richard J. Simpson, Walter Weiss, Michael J. Dunn

Research output: Contribution to journalReview article

254 Citations (Scopus)

Abstract

In the last ten years, the field of proteomics has expanded at a rapid rate. A range of exciting new technology has been developed and enthusiastically applied to an enormous variety of biological questions. However, the degree of stringency required in proteomic data generation and analysis appears to have been underestimated. As a result, there are likely to be numerous published findings that are of questionable quality, requiring further confirmation and/or validation. This manuscript outlines a number of key issues in proteomic research, including those associated with experimental design, differential display and biomarker discovery, protein identification and analytical incompleteness. In an effort to set a standard that reflects current thinking on the necessary and desirable characteristics of publishable manuscripts in the field, a minimal set of guidelines for proteomics research is then described. These guidelines will serve as a set of criteria which editors of PROTEOMICS will use for assessment of future submissions to the Journal.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
JournalProteomics
Volume6
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

Fingerprint

Proteomics
Guidelines
Manuscripts
Biomarkers
Research
Design of experiments
Research Design
Display devices
Technology
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Wilkins, M. R., Appel, R. D., Van Eyk, J. E., Chung, M. C. M., Görg, A., Hecker, M., ... Dunn, M. J. (2006). Guidelines for the next 10 years of proteomics. Proteomics, 6(1), 4-8. https://doi.org/10.1002/pmic.200500856
Wilkins, Marc R. ; Appel, Ron D. ; Van Eyk, Jennifer E. ; Chung, Maxey C.M. ; Görg, Angelika ; Hecker, Michael ; Huber, Lukas A. ; Langen, Hanno ; Link, Andrew J. ; Paik, Young-Ki ; Patterson, Scott D. ; Pennington, Stephen R. ; Rabilloud, Thierry ; Simpson, Richard J. ; Weiss, Walter ; Dunn, Michael J. / Guidelines for the next 10 years of proteomics. In: Proteomics. 2006 ; Vol. 6, No. 1. pp. 4-8.
@article{605169e79cf545eb9dba2e1a6c809590,
title = "Guidelines for the next 10 years of proteomics",
abstract = "In the last ten years, the field of proteomics has expanded at a rapid rate. A range of exciting new technology has been developed and enthusiastically applied to an enormous variety of biological questions. However, the degree of stringency required in proteomic data generation and analysis appears to have been underestimated. As a result, there are likely to be numerous published findings that are of questionable quality, requiring further confirmation and/or validation. This manuscript outlines a number of key issues in proteomic research, including those associated with experimental design, differential display and biomarker discovery, protein identification and analytical incompleteness. In an effort to set a standard that reflects current thinking on the necessary and desirable characteristics of publishable manuscripts in the field, a minimal set of guidelines for proteomics research is then described. These guidelines will serve as a set of criteria which editors of PROTEOMICS will use for assessment of future submissions to the Journal.",
author = "Wilkins, {Marc R.} and Appel, {Ron D.} and {Van Eyk}, {Jennifer E.} and Chung, {Maxey C.M.} and Angelika G{\"o}rg and Michael Hecker and Huber, {Lukas A.} and Hanno Langen and Link, {Andrew J.} and Young-Ki Paik and Patterson, {Scott D.} and Pennington, {Stephen R.} and Thierry Rabilloud and Simpson, {Richard J.} and Walter Weiss and Dunn, {Michael J.}",
year = "2006",
month = "1",
day = "1",
doi = "10.1002/pmic.200500856",
language = "English",
volume = "6",
pages = "4--8",
journal = "Proteomics",
issn = "1615-9853",
publisher = "Wiley-VCH Verlag",
number = "1",

}

Wilkins, MR, Appel, RD, Van Eyk, JE, Chung, MCM, Görg, A, Hecker, M, Huber, LA, Langen, H, Link, AJ, Paik, Y-K, Patterson, SD, Pennington, SR, Rabilloud, T, Simpson, RJ, Weiss, W & Dunn, MJ 2006, 'Guidelines for the next 10 years of proteomics', Proteomics, vol. 6, no. 1, pp. 4-8. https://doi.org/10.1002/pmic.200500856

Guidelines for the next 10 years of proteomics. / Wilkins, Marc R.; Appel, Ron D.; Van Eyk, Jennifer E.; Chung, Maxey C.M.; Görg, Angelika; Hecker, Michael; Huber, Lukas A.; Langen, Hanno; Link, Andrew J.; Paik, Young-Ki; Patterson, Scott D.; Pennington, Stephen R.; Rabilloud, Thierry; Simpson, Richard J.; Weiss, Walter; Dunn, Michael J.

In: Proteomics, Vol. 6, No. 1, 01.01.2006, p. 4-8.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Guidelines for the next 10 years of proteomics

AU - Wilkins, Marc R.

AU - Appel, Ron D.

AU - Van Eyk, Jennifer E.

AU - Chung, Maxey C.M.

AU - Görg, Angelika

AU - Hecker, Michael

AU - Huber, Lukas A.

AU - Langen, Hanno

AU - Link, Andrew J.

AU - Paik, Young-Ki

AU - Patterson, Scott D.

AU - Pennington, Stephen R.

AU - Rabilloud, Thierry

AU - Simpson, Richard J.

AU - Weiss, Walter

AU - Dunn, Michael J.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - In the last ten years, the field of proteomics has expanded at a rapid rate. A range of exciting new technology has been developed and enthusiastically applied to an enormous variety of biological questions. However, the degree of stringency required in proteomic data generation and analysis appears to have been underestimated. As a result, there are likely to be numerous published findings that are of questionable quality, requiring further confirmation and/or validation. This manuscript outlines a number of key issues in proteomic research, including those associated with experimental design, differential display and biomarker discovery, protein identification and analytical incompleteness. In an effort to set a standard that reflects current thinking on the necessary and desirable characteristics of publishable manuscripts in the field, a minimal set of guidelines for proteomics research is then described. These guidelines will serve as a set of criteria which editors of PROTEOMICS will use for assessment of future submissions to the Journal.

AB - In the last ten years, the field of proteomics has expanded at a rapid rate. A range of exciting new technology has been developed and enthusiastically applied to an enormous variety of biological questions. However, the degree of stringency required in proteomic data generation and analysis appears to have been underestimated. As a result, there are likely to be numerous published findings that are of questionable quality, requiring further confirmation and/or validation. This manuscript outlines a number of key issues in proteomic research, including those associated with experimental design, differential display and biomarker discovery, protein identification and analytical incompleteness. In an effort to set a standard that reflects current thinking on the necessary and desirable characteristics of publishable manuscripts in the field, a minimal set of guidelines for proteomics research is then described. These guidelines will serve as a set of criteria which editors of PROTEOMICS will use for assessment of future submissions to the Journal.

UR - http://www.scopus.com/inward/record.url?scp=31344448066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31344448066&partnerID=8YFLogxK

U2 - 10.1002/pmic.200500856

DO - 10.1002/pmic.200500856

M3 - Review article

VL - 6

SP - 4

EP - 8

JO - Proteomics

JF - Proteomics

SN - 1615-9853

IS - 1

ER -

Wilkins MR, Appel RD, Van Eyk JE, Chung MCM, Görg A, Hecker M et al. Guidelines for the next 10 years of proteomics. Proteomics. 2006 Jan 1;6(1):4-8. https://doi.org/10.1002/pmic.200500856