Guidelines of prevention and treatment for NSAID-related peptic ulcers

Jun Haeng Lee, Yong Chan Lee, Seong Woo Jeon, Jeong Wook Kim, Sang Woo Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications in Korea. Gastrointestinal toxicity, including peptic ulcer, is a common adverse effect of NSAIDs. Risk factors for NSAID-related peptic ulcer include a previous history of peptic ulcer, advanced age, high dose, concomitant use of corticosteroids, anticoagulants, other NSAIDs including low-dose aspirin. Preventive measure(s), such as COX-2 inhibitor, proton pump inhibitor or misoprostrol, should be done for patients requiring NSAID therapy who have high-risk factor(s) for peptic ulcer. Low dose aspirin also increases the risk of peptic ulcer, so preventive measure(s) should be done for high-risk patients. The eradication of Helicobacter pylori is recommended for high-risk NSAID-users. Treatment strategies for peptic ulcers in NSAID users are mostly the same for peptic ulcers in NSAID non-users.

Original languageEnglish
Pages (from-to)309-317
Number of pages9
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume54
Issue number5
DOIs
Publication statusPublished - 2009 Nov

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Peptic Ulcer
Anti-Inflammatory Agents
Guidelines
Pharmaceutical Preparations
Drug Users
Therapeutics
Aspirin
Proton Pump Inhibitors
Cyclooxygenase 2 Inhibitors
Korea
Helicobacter pylori
Anticoagulants
Adrenal Cortex Hormones
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Jun Haeng ; Lee, Yong Chan ; Jeon, Seong Woo ; Kim, Jeong Wook ; Lee, Sang Woo. / Guidelines of prevention and treatment for NSAID-related peptic ulcers. In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2009 ; Vol. 54, No. 5. pp. 309-317.
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Guidelines of prevention and treatment for NSAID-related peptic ulcers. / Lee, Jun Haeng; Lee, Yong Chan; Jeon, Seong Woo; Kim, Jeong Wook; Lee, Sang Woo.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 54, No. 5, 11.2009, p. 309-317.

Research output: Contribution to journalArticle

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