Hairless plays a role in formation of inner root sheath via regulation of Dlx3 gene

Bong Kyu Kim, Hwa Young Lee, Jee Hyun Choi, Jeong Ki Kim, Jong Bok Yoon, Sungjoo Kim Yoon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The Hairless (Hr), a transcription factor, is expressed in the suprabasal cell layer of the interfollicular epidermis and the lower portion of the hair follicle epithelium, where its expression is dependent on the hair cycle. Recently, we reported a new Hr mutant mouse, HrHp, in which the hairless protein (HR) was overexpressed. In this study, we documented abnormal formation of inner root sheath (IRS), suppressed expression of Dlx3, and IRS keratins in the HrHp/HrHp skin. We also found that HR down-regulated Dlx3 mRNA expression through suppression of Dlx3 promoter activity. In addition, we showed that Dlx3 regulated the expression of IRS keratins. Our results demonstrate that regulation of Dlx3 by HR affects the IRS keratin expression, thus modulating the formation of IRS of hair follicle.

Original languageEnglish
Pages (from-to)16681-16688
Number of pages8
JournalJournal of Biological Chemistry
Volume287
Issue number20
DOIs
Publication statusPublished - 2012 May 11

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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