Haplotype combination of Calpain-10 gene polymorphism is associated with metabolic syndrome in type 2 diabetes

Eun Seok Kang, Moonsuk Nam, Hye Joo Kim, Hyeong Jin Kim, Sung Min Myoung, Yumie Rhee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Patients with metabolic syndrome are at increased risk of developing cardiovascular disease. The combinations of the haplotype created by the alleles of three single nucleotide polymorphisms (SNPs): SNP-43, -19, and -63 of the Calpain-10 gene (CAPN10), have been reported to be associated with the risk of type 2 diabetes in many populations. The aim of this study was to examine the association of the CAPN10 polymorphism with metabolic syndrome in patients with type 2 diabetes in Korea. Overall, 382 patients with type 2 diabetes were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, -19, and -63. The restriction fragment length polymorphism method was used for the three SNPs. The baseline presence of components of metabolic syndrome was determined. Two hundred and sixty-five (69.4%) patients had metabolic syndrome. Patients with the 111/121 haplotype combination showed a higher risk of hypertension than the other haplotype combinations (odd ratio (OR) = 2.334, P = 0.010). Patients with the 111/121 haplotype combination had a significantly high risk of metabolic syndrome (OR = 1.927, P = 0.042). The results of this study suggest that a novel 111/121 haplotype combination created by the CAPN10 SNP-43, -19, and -63 increases the susceptibility to the metabolic syndrome in patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume73
Issue number3
DOIs
Publication statusPublished - 2006 Sep

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Haplotype combination of Calpain-10 gene polymorphism is associated with metabolic syndrome in type 2 diabetes'. Together they form a unique fingerprint.

  • Cite this