HBV genotypes: Relevance to natural history, pathogenesis and treatment of chronic hepatitis B

Beom Kyung Kim, Peter A. Revill, Sang Hoon Ahn

Research output: Contribution to journalReview articlepeer-review

113 Citations (Scopus)

Abstract

Although chronic HBV infection is the leading cause of chronic liver disease and death worldwide, there are substantial differences in its clinical courses regarding prevalence, mode of transmission, characteristics of each phase, responses to antiviral therapy, and development of cirrhosis and hepatocellular carcinoma, according to geographical areas (Asia versus Western Europe and North America versus Africa). Furthermore, the clinical course in infected individuals depends on a complex interplay among various factors including viral, host, environmental and other factors. Recently, understanding of molecular characteristics of the prevailing HBV genotypes, frequently accompanied mutations and their clinical implications might explain these geographical differences more pertinently. Hence, in this article, we review the global epidemiology and the natural history of HBV infection, with emphasis on summarizing the different HBV genotypes according to regions.

Original languageEnglish
Pages (from-to)1169-1186
Number of pages18
JournalAntiviral therapy
Volume16
Issue number8
DOIs
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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