Head to head comparison of [ 18 F] AV-1451 and [ 18 F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia

Young Kyoung Jang, Chulhyoung Lyoo, Seongbeom Park, Seung Jun Oh, Hanna Cho, Minyoung Oh, Young Hoon Ryu, Jae Yong Choi, Gil D. Rabinovici, Hee Jin Kim, Seung Hwan Moon, Hyemin Jang, Jin San Lee, William J. Jagust, Duk L. Na, Jae Seung Kim, Sang Won Seo

Research output: Contribution to journalArticle

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Abstract

Purpose: Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [ 18 F] AV-1451 and [ 18 F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer’s disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders. Methods: A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer’s disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [ 18 F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter. Results: Although THK5351 and AV-1451 uptakes were highly correlated, cortical uptake of AV-1451 was more striking in Alzheimer’s disease, while cortical uptake of THK5351 was more prominent in frontotemporal dementia. THK5351 showed higher off-target binding than AV-1451 in the white matter, midbrain, thalamus, and basal ganglia. Conclusions: AV-1451 is more sensitive and specific to Alzheimer’s disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.

Original languageEnglish
Pages (from-to)432-442
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume45
Issue number3
DOIs
Publication statusPublished - 2018 Mar 1

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Frontotemporal Dementia
Alzheimer Disease
Positron-Emission Tomography
Frontotemporal Lobar Degeneration
Mesencephalon
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
THK5351
Basal Ganglia
Thalamus
Amyloid
Tertiary Care Centers
Neurodegenerative Diseases
Magnetic Resonance Spectroscopy
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Jang, Young Kyoung ; Lyoo, Chulhyoung ; Park, Seongbeom ; Oh, Seung Jun ; Cho, Hanna ; Oh, Minyoung ; Ryu, Young Hoon ; Choi, Jae Yong ; Rabinovici, Gil D. ; Kim, Hee Jin ; Moon, Seung Hwan ; Jang, Hyemin ; Lee, Jin San ; Jagust, William J. ; Na, Duk L. ; Kim, Jae Seung ; Seo, Sang Won. / Head to head comparison of [ 18 F] AV-1451 and [ 18 F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia In: European Journal of Nuclear Medicine and Molecular Imaging. 2018 ; Vol. 45, No. 3. pp. 432-442.
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title = "Head to head comparison of [ 18 F] AV-1451 and [ 18 F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia",
abstract = "Purpose: Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [ 18 F] AV-1451 and [ 18 F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer’s disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders. Methods: A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer’s disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [ 18 F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter. Results: Although THK5351 and AV-1451 uptakes were highly correlated, cortical uptake of AV-1451 was more striking in Alzheimer’s disease, while cortical uptake of THK5351 was more prominent in frontotemporal dementia. THK5351 showed higher off-target binding than AV-1451 in the white matter, midbrain, thalamus, and basal ganglia. Conclusions: AV-1451 is more sensitive and specific to Alzheimer’s disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.",
author = "Jang, {Young Kyoung} and Chulhyoung Lyoo and Seongbeom Park and Oh, {Seung Jun} and Hanna Cho and Minyoung Oh and Ryu, {Young Hoon} and Choi, {Jae Yong} and Rabinovici, {Gil D.} and Kim, {Hee Jin} and Moon, {Seung Hwan} and Hyemin Jang and Lee, {Jin San} and Jagust, {William J.} and Na, {Duk L.} and Kim, {Jae Seung} and Seo, {Sang Won}",
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Jang, YK, Lyoo, C, Park, S, Oh, SJ, Cho, H, Oh, M, Ryu, YH, Choi, JY, Rabinovici, GD, Kim, HJ, Moon, SH, Jang, H, Lee, JS, Jagust, WJ, Na, DL, Kim, JS & Seo, SW 2018, ' Head to head comparison of [ 18 F] AV-1451 and [ 18 F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 45, no. 3, pp. 432-442. https://doi.org/10.1007/s00259-017-3876-0

Head to head comparison of [ 18 F] AV-1451 and [ 18 F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia . / Jang, Young Kyoung; Lyoo, Chulhyoung; Park, Seongbeom; Oh, Seung Jun; Cho, Hanna; Oh, Minyoung; Ryu, Young Hoon; Choi, Jae Yong; Rabinovici, Gil D.; Kim, Hee Jin; Moon, Seung Hwan; Jang, Hyemin; Lee, Jin San; Jagust, William J.; Na, Duk L.; Kim, Jae Seung; Seo, Sang Won.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No. 3, 01.03.2018, p. 432-442.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Head to head comparison of [ 18 F] AV-1451 and [ 18 F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia

AU - Jang, Young Kyoung

AU - Lyoo, Chulhyoung

AU - Park, Seongbeom

AU - Oh, Seung Jun

AU - Cho, Hanna

AU - Oh, Minyoung

AU - Ryu, Young Hoon

AU - Choi, Jae Yong

AU - Rabinovici, Gil D.

AU - Kim, Hee Jin

AU - Moon, Seung Hwan

AU - Jang, Hyemin

AU - Lee, Jin San

AU - Jagust, William J.

AU - Na, Duk L.

AU - Kim, Jae Seung

AU - Seo, Sang Won

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose: Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [ 18 F] AV-1451 and [ 18 F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer’s disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders. Methods: A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer’s disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [ 18 F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter. Results: Although THK5351 and AV-1451 uptakes were highly correlated, cortical uptake of AV-1451 was more striking in Alzheimer’s disease, while cortical uptake of THK5351 was more prominent in frontotemporal dementia. THK5351 showed higher off-target binding than AV-1451 in the white matter, midbrain, thalamus, and basal ganglia. Conclusions: AV-1451 is more sensitive and specific to Alzheimer’s disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.

AB - Purpose: Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [ 18 F] AV-1451 and [ 18 F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer’s disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders. Methods: A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer’s disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [ 18 F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter. Results: Although THK5351 and AV-1451 uptakes were highly correlated, cortical uptake of AV-1451 was more striking in Alzheimer’s disease, while cortical uptake of THK5351 was more prominent in frontotemporal dementia. THK5351 showed higher off-target binding than AV-1451 in the white matter, midbrain, thalamus, and basal ganglia. Conclusions: AV-1451 is more sensitive and specific to Alzheimer’s disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.

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JO - European Journal of Nuclear Medicine and Molecular Imaging

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