Abstract
Background: The goal of this study was to evaluate the quality of life (QOL) of Asian children with pre-dialysis chronic kidney disease (CKD) and to reveal the factors influencing the QOL of children with CKD. Methods: We performed a cross-sectional study of the PedsQL 4.0 Generic Core Scale Module in the KNOW-PedCKD (KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease) cohort, and compared the child self-reported and parent proxy-reported QOL of the pediatric cohort. From 2011 through 2016, a total of 376 children with CKD were enrolled after informed consent was obtained from parents or caregivers in seven pediatric nephrology centers. Results: In parent proxy-reports, male patients had a better QOL than female patients in the Physical Functioning category. In child self-reports, male patients had better QOL than female patients in the Physical, Emotional, and School Functioning categories. According to CKD stage, there were significant differences in the QOL score in all categories of parent proxy-reports, and patients with higher CKD stage (lower glomerular filtration rate) had a worse QOL. Growth parameters showed a significantly positive correlation with the QOL score in all categories. Conclusions: The QOL of children with predialysis CKD is affected by various factors, including sex, glomerular filtration rate (GFR), socio-economic status, existence of co-morbidities, anemia, growth retardation, and behavioral disorders. To improve their QOL, it is important to objectively understand the respective effects of these factors and attempt early intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 2097-2105 |
| Number of pages | 9 |
| Journal | Pediatric Nephrology |
| Volume | 32 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2017 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Nephrology
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Health-related quality of life of children with pre-dialysis chronic kidney disease. / Baek, Hee Sun; Kang, Hee Gyung; Choi, Hyun Jin; Cheong, Hae Il; Ha, Il Soo; Han, Kyung Hee; Kim, Seong Heon; Cho, Hee Yeon; Shin, Jae Il; Park, Young Seo; Lee, Joo Hoon; Lee, Joongyub; Ahn, Curie; Cho, Min Hyun.
In: Pediatric Nephrology, Vol. 32, No. 11, 01.11.2017, p. 2097-2105.Research output: Contribution to journal › Article
TY - JOUR
T1 - Health-related quality of life of children with pre-dialysis chronic kidney disease
AU - Baek, Hee Sun
AU - Kang, Hee Gyung
AU - Choi, Hyun Jin
AU - Cheong, Hae Il
AU - Ha, Il Soo
AU - Han, Kyung Hee
AU - Kim, Seong Heon
AU - Cho, Hee Yeon
AU - Shin, Jae Il
AU - Park, Young Seo
AU - Lee, Joo Hoon
AU - Lee, Joongyub
AU - Ahn, Curie
AU - Cho, Min Hyun
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background: The goal of this study was to evaluate the quality of life (QOL) of Asian children with pre-dialysis chronic kidney disease (CKD) and to reveal the factors influencing the QOL of children with CKD. Methods: We performed a cross-sectional study of the PedsQL 4.0 Generic Core Scale Module in the KNOW-PedCKD (KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease) cohort, and compared the child self-reported and parent proxy-reported QOL of the pediatric cohort. From 2011 through 2016, a total of 376 children with CKD were enrolled after informed consent was obtained from parents or caregivers in seven pediatric nephrology centers. Results: In parent proxy-reports, male patients had a better QOL than female patients in the Physical Functioning category. In child self-reports, male patients had better QOL than female patients in the Physical, Emotional, and School Functioning categories. According to CKD stage, there were significant differences in the QOL score in all categories of parent proxy-reports, and patients with higher CKD stage (lower glomerular filtration rate) had a worse QOL. Growth parameters showed a significantly positive correlation with the QOL score in all categories. Conclusions: The QOL of children with predialysis CKD is affected by various factors, including sex, glomerular filtration rate (GFR), socio-economic status, existence of co-morbidities, anemia, growth retardation, and behavioral disorders. To improve their QOL, it is important to objectively understand the respective effects of these factors and attempt early intervention.
AB - Background: The goal of this study was to evaluate the quality of life (QOL) of Asian children with pre-dialysis chronic kidney disease (CKD) and to reveal the factors influencing the QOL of children with CKD. Methods: We performed a cross-sectional study of the PedsQL 4.0 Generic Core Scale Module in the KNOW-PedCKD (KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease) cohort, and compared the child self-reported and parent proxy-reported QOL of the pediatric cohort. From 2011 through 2016, a total of 376 children with CKD were enrolled after informed consent was obtained from parents or caregivers in seven pediatric nephrology centers. Results: In parent proxy-reports, male patients had a better QOL than female patients in the Physical Functioning category. In child self-reports, male patients had better QOL than female patients in the Physical, Emotional, and School Functioning categories. According to CKD stage, there were significant differences in the QOL score in all categories of parent proxy-reports, and patients with higher CKD stage (lower glomerular filtration rate) had a worse QOL. Growth parameters showed a significantly positive correlation with the QOL score in all categories. Conclusions: The QOL of children with predialysis CKD is affected by various factors, including sex, glomerular filtration rate (GFR), socio-economic status, existence of co-morbidities, anemia, growth retardation, and behavioral disorders. To improve their QOL, it is important to objectively understand the respective effects of these factors and attempt early intervention.
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UR - http://www.scopus.com/inward/citedby.url?scp=85022020087&partnerID=8YFLogxK
U2 - 10.1007/s00467-017-3721-5
DO - 10.1007/s00467-017-3721-5
M3 - Article
C2 - 28685173
AN - SCOPUS:85022020087
VL - 32
SP - 2097
EP - 2105
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 11
ER -