Helical α/β-depsipeptides with alternating residue types: Conformational change from the 11-helix to the 14/15-helix

Jaeyeon Lee, Geunhyeok Jang, Philjae Kang, Moon Gun Choi, Soo Hyuk Choi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Short α/β-peptides that consist of alternating l-α-amino acids and trans-2-aminocyclopentanecarboxylic acid are known to adopt both 11- and 14/15-helical conformations in solution. We report short α/β-depsipeptides containing (S)-lactic acid as the third residue from the N-terminus. The α/β-depsipeptide pentamers and heptamers adopt 14/15-helical conformations analogous to the α-helix in the crystal state and display 14/15-helical conformations predominantly in solution.

Original languageEnglish
Pages (from-to)8438-8442
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number36
DOIs
Publication statusPublished - 2016 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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