Abstract
Many important biological functions involve the recognition of helical domains of natural proteins. A number of strategies have been developed to mimic natural helices in proteins. Unnatural peptides are constructed with incorporation of artificial building blocks other than α-amino acid residues, and could adopt stable helical conformations. These nontraditional helical oligomers have been explored to mimic biological functions involved with helical domains of natural proteins. This review provides representative examples of the mimicry of natural peptide helices with unnatural ones and related biological applications.
| Original language | English |
|---|---|
| Pages (from-to) | 226-231 |
| Number of pages | 6 |
| Journal | Biomedical Engineering Letters |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2013 Dec |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
Cite this
}
Helical structures of unnatural peptides for biological applications. / Choi, Soo Hyuk.
In: Biomedical Engineering Letters, Vol. 3, No. 4, 12.2013, p. 226-231.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Helical structures of unnatural peptides for biological applications
AU - Choi, Soo Hyuk
PY - 2013/12
Y1 - 2013/12
N2 - Many important biological functions involve the recognition of helical domains of natural proteins. A number of strategies have been developed to mimic natural helices in proteins. Unnatural peptides are constructed with incorporation of artificial building blocks other than α-amino acid residues, and could adopt stable helical conformations. These nontraditional helical oligomers have been explored to mimic biological functions involved with helical domains of natural proteins. This review provides representative examples of the mimicry of natural peptide helices with unnatural ones and related biological applications.
AB - Many important biological functions involve the recognition of helical domains of natural proteins. A number of strategies have been developed to mimic natural helices in proteins. Unnatural peptides are constructed with incorporation of artificial building blocks other than α-amino acid residues, and could adopt stable helical conformations. These nontraditional helical oligomers have been explored to mimic biological functions involved with helical domains of natural proteins. This review provides representative examples of the mimicry of natural peptide helices with unnatural ones and related biological applications.
UR - http://www.scopus.com/inward/record.url?scp=84892464507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892464507&partnerID=8YFLogxK
U2 - 10.1007/s13534-013-0116-9
DO - 10.1007/s13534-013-0116-9
M3 - Review article
AN - SCOPUS:84892464507
VL - 3
SP - 226
EP - 231
JO - Biomedical Engineering Letters
JF - Biomedical Engineering Letters
SN - 2093-9868
IS - 4
ER -