Helical structures of unnatural peptides for biological applications

Soo Hyuk Choi

doi:10.1007/s13534-013-0116-9

Helical structures of unnatural peptides for biological applications

Soo Hyuk Choi

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Many important biological functions involve the recognition of helical domains of natural proteins. A number of strategies have been developed to mimic natural helices in proteins. Unnatural peptides are constructed with incorporation of artificial building blocks other than α-amino acid residues, and could adopt stable helical conformations. These nontraditional helical oligomers have been explored to mimic biological functions involved with helical domains of natural proteins. This review provides representative examples of the mimicry of natural peptide helices with unnatural ones and related biological applications.

Original language	English
Pages (from-to)	226-231
Number of pages	6
Journal	Biomedical Engineering Letters
Volume	3
Issue number	4
DOIs	https://doi.org/10.1007/s13534-013-0116-9
Publication status	Published - 2013 Dec

All Science Journal Classification (ASJC) codes

Biomedical Engineering

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