TY - JOUR
T1 - Helicobacter pylori eradication on iatrogenic ulcer by endoscopic resection of gastric tumour
T2 - A prospective, randomized, placebo-controlled multi-centre trial
AU - Kim, Sang Gyun
AU - Song, Ho June
AU - Choi, Il Ju
AU - Cho, Won Young
AU - Lee, Jeong Hoon
AU - Keum, Bora
AU - Lee, Yong Chan
AU - Kim, Jae Gyu
AU - Park, Sue K.
AU - Park, Byung Joo
AU - Jung, Hyun Chae
N1 - Funding Information:
All authors disclosed no financial relationships relevant to this publication. This work was supported by the Korean College of Helicobacter and Upper Gastrointestinal Research.
PY - 2013/5
Y1 - 2013/5
N2 - Introduction: The role of Helicobacter pylori (. H. pylori) eradication has not been clarified in the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. The aim of this study was to evaluate whether H. pylori eradication could facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. Methods: A total of 232 patients with H. pylori-positive early gastric cancer or gastric adenoma underwent endoscopic resection and were randomly allocated to eradication or placebo group in a prospective, double-blinded, and placebo-controlled manner. The primary outcome was measured by healing rate of ulcer, and the secondary outcomes by reduction rate of ulcer size, relief rate from ulcer-related symptoms, and adverse event rates. Results: The healing rate of ulcer was 53% in eradication group and 51.6% in placebo group, respectively (. p value. =. 0.95). The reduction rate of ulcer size, relief rate from ulcer-related symptoms and adverse event rates were also not different between two groups. In multivariate analysis, initial ulcer size more than 3. cm and histology of cancer were significant factors affecting iatrogenic ulcer healing. Conclusions: H. pylori eradication did not facilitate iatrogenic ulcer healing at early and late phase after endoscopic resection of gastric neoplasm.
AB - Introduction: The role of Helicobacter pylori (. H. pylori) eradication has not been clarified in the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. The aim of this study was to evaluate whether H. pylori eradication could facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. Methods: A total of 232 patients with H. pylori-positive early gastric cancer or gastric adenoma underwent endoscopic resection and were randomly allocated to eradication or placebo group in a prospective, double-blinded, and placebo-controlled manner. The primary outcome was measured by healing rate of ulcer, and the secondary outcomes by reduction rate of ulcer size, relief rate from ulcer-related symptoms, and adverse event rates. Results: The healing rate of ulcer was 53% in eradication group and 51.6% in placebo group, respectively (. p value. =. 0.95). The reduction rate of ulcer size, relief rate from ulcer-related symptoms and adverse event rates were also not different between two groups. In multivariate analysis, initial ulcer size more than 3. cm and histology of cancer were significant factors affecting iatrogenic ulcer healing. Conclusions: H. pylori eradication did not facilitate iatrogenic ulcer healing at early and late phase after endoscopic resection of gastric neoplasm.
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U2 - 10.1016/j.dld.2012.12.009
DO - 10.1016/j.dld.2012.12.009
M3 - Article
C2 - 23333104
AN - SCOPUS:84876719789
VL - 45
SP - 385
EP - 389
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 5
ER -
