Helicobacter pylori eradication reduces the metachronous recurrence of gastric neoplasms by attenuating the precancerous process

Hyun Da Jung, Jie Hyun Kim, Yong Chan Lee, Sang Kil Lee, Sung Kwan Shin, Jun Chul Park, Hyun Soo Chung, Hyunki Kim, Hoguen Kim, Yong Hoon Kim, Jae Jun Park, Young Hoon Youn, Hyojin Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: The importance of Helicobacter pylori eradication after endoscopic resection (ER) of gastric neoplasms remains controversial. In this study, we clarified the importance of H. pylori eradication for metachronous lesions after ER. Materials and Methods: This study included 3,882 patients with gastric neoplasms who underwent ER. We included patients infected with H. pylori who received eradication therapy. Among them, 34 patients with metachronous lesions after ER and 102 age and sexmatched patients (nonmetachronous group) were enrolled. Background mucosal pathologies such as atrophy and intestinal metaplasia (IM) were evaluated endoscopically. The expression levels of CDX1, CDX2, Sonic hedgehog (SHH), and SOX2 were evaluated based on H. pylori eradication and the development of metachronous lesions. Results: The eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.036). Opentype atrophy (P=0.003) and moderate-to-severe IM (P=0.001) occurred more frequently in the metachronous group. In patients with an initial diagnosis of dysplasia, the eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.002). In addition, open-type atrophy was more frequent in the metachronous group (P=0.047). In patients with an initial diagnosis of carcinoma, moderate-to-severe IM occurred more frequently in the metachronous group (P=0.003); however, the eradication failure rate was not significantly different between the two groups. SHH and SOX2 expression was increased, and CDX2 expression was decreased in the nonmetachronous group after eradication (P<0.05). Conclusions: Open-type atrophy, moderate-to-severe IM, and H. pylori eradication failure were significantly associated with metachronous lesions. However, eradication failure was significantly associated with dysplasia, but not carcinoma, in the metachronous group. Thus, H. pylori eradication may play an important role in preventing metachronous lesions after ER for precancerous lesions before carcinomatous transformation.

Original languageEnglish
Pages (from-to)246-255
Number of pages10
JournalJournal of Gastric Cancer
Volume15
Issue number4
DOIs
Publication statusPublished - 2015 Jan 1

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Helicobacter pylori
Stomach Neoplasms
Metaplasia
Recurrence
Atrophy
Carcinoma
Pathology
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology
  • Cancer Research

Cite this

Da Jung, Hyun ; Kim, Jie Hyun ; Lee, Yong Chan ; Lee, Sang Kil ; Shin, Sung Kwan ; Park, Jun Chul ; Chung, Hyun Soo ; Kim, Hyunki ; Kim, Hoguen ; Kim, Yong Hoon ; Park, Jae Jun ; Youn, Young Hoon ; Park, Hyojin. / Helicobacter pylori eradication reduces the metachronous recurrence of gastric neoplasms by attenuating the precancerous process. In: Journal of Gastric Cancer. 2015 ; Vol. 15, No. 4. pp. 246-255.
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title = "Helicobacter pylori eradication reduces the metachronous recurrence of gastric neoplasms by attenuating the precancerous process",
abstract = "Purpose: The importance of Helicobacter pylori eradication after endoscopic resection (ER) of gastric neoplasms remains controversial. In this study, we clarified the importance of H. pylori eradication for metachronous lesions after ER. Materials and Methods: This study included 3,882 patients with gastric neoplasms who underwent ER. We included patients infected with H. pylori who received eradication therapy. Among them, 34 patients with metachronous lesions after ER and 102 age and sexmatched patients (nonmetachronous group) were enrolled. Background mucosal pathologies such as atrophy and intestinal metaplasia (IM) were evaluated endoscopically. The expression levels of CDX1, CDX2, Sonic hedgehog (SHH), and SOX2 were evaluated based on H. pylori eradication and the development of metachronous lesions. Results: The eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.036). Opentype atrophy (P=0.003) and moderate-to-severe IM (P=0.001) occurred more frequently in the metachronous group. In patients with an initial diagnosis of dysplasia, the eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.002). In addition, open-type atrophy was more frequent in the metachronous group (P=0.047). In patients with an initial diagnosis of carcinoma, moderate-to-severe IM occurred more frequently in the metachronous group (P=0.003); however, the eradication failure rate was not significantly different between the two groups. SHH and SOX2 expression was increased, and CDX2 expression was decreased in the nonmetachronous group after eradication (P<0.05). Conclusions: Open-type atrophy, moderate-to-severe IM, and H. pylori eradication failure were significantly associated with metachronous lesions. However, eradication failure was significantly associated with dysplasia, but not carcinoma, in the metachronous group. Thus, H. pylori eradication may play an important role in preventing metachronous lesions after ER for precancerous lesions before carcinomatous transformation.",
author = "{Da Jung}, Hyun and Kim, {Jie Hyun} and Lee, {Yong Chan} and Lee, {Sang Kil} and Shin, {Sung Kwan} and Park, {Jun Chul} and Chung, {Hyun Soo} and Hyunki Kim and Hoguen Kim and Kim, {Yong Hoon} and Park, {Jae Jun} and Youn, {Young Hoon} and Hyojin Park",
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Helicobacter pylori eradication reduces the metachronous recurrence of gastric neoplasms by attenuating the precancerous process. / Da Jung, Hyun; Kim, Jie Hyun; Lee, Yong Chan; Lee, Sang Kil; Shin, Sung Kwan; Park, Jun Chul; Chung, Hyun Soo; Kim, Hyunki; Kim, Hoguen; Kim, Yong Hoon; Park, Jae Jun; Youn, Young Hoon; Park, Hyojin.

In: Journal of Gastric Cancer, Vol. 15, No. 4, 01.01.2015, p. 246-255.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Helicobacter pylori eradication reduces the metachronous recurrence of gastric neoplasms by attenuating the precancerous process

AU - Da Jung, Hyun

AU - Kim, Jie Hyun

AU - Lee, Yong Chan

AU - Lee, Sang Kil

AU - Shin, Sung Kwan

AU - Park, Jun Chul

AU - Chung, Hyun Soo

AU - Kim, Hyunki

AU - Kim, Hoguen

AU - Kim, Yong Hoon

AU - Park, Jae Jun

AU - Youn, Young Hoon

AU - Park, Hyojin

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: The importance of Helicobacter pylori eradication after endoscopic resection (ER) of gastric neoplasms remains controversial. In this study, we clarified the importance of H. pylori eradication for metachronous lesions after ER. Materials and Methods: This study included 3,882 patients with gastric neoplasms who underwent ER. We included patients infected with H. pylori who received eradication therapy. Among them, 34 patients with metachronous lesions after ER and 102 age and sexmatched patients (nonmetachronous group) were enrolled. Background mucosal pathologies such as atrophy and intestinal metaplasia (IM) were evaluated endoscopically. The expression levels of CDX1, CDX2, Sonic hedgehog (SHH), and SOX2 were evaluated based on H. pylori eradication and the development of metachronous lesions. Results: The eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.036). Opentype atrophy (P=0.003) and moderate-to-severe IM (P=0.001) occurred more frequently in the metachronous group. In patients with an initial diagnosis of dysplasia, the eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.002). In addition, open-type atrophy was more frequent in the metachronous group (P=0.047). In patients with an initial diagnosis of carcinoma, moderate-to-severe IM occurred more frequently in the metachronous group (P=0.003); however, the eradication failure rate was not significantly different between the two groups. SHH and SOX2 expression was increased, and CDX2 expression was decreased in the nonmetachronous group after eradication (P<0.05). Conclusions: Open-type atrophy, moderate-to-severe IM, and H. pylori eradication failure were significantly associated with metachronous lesions. However, eradication failure was significantly associated with dysplasia, but not carcinoma, in the metachronous group. Thus, H. pylori eradication may play an important role in preventing metachronous lesions after ER for precancerous lesions before carcinomatous transformation.

AB - Purpose: The importance of Helicobacter pylori eradication after endoscopic resection (ER) of gastric neoplasms remains controversial. In this study, we clarified the importance of H. pylori eradication for metachronous lesions after ER. Materials and Methods: This study included 3,882 patients with gastric neoplasms who underwent ER. We included patients infected with H. pylori who received eradication therapy. Among them, 34 patients with metachronous lesions after ER and 102 age and sexmatched patients (nonmetachronous group) were enrolled. Background mucosal pathologies such as atrophy and intestinal metaplasia (IM) were evaluated endoscopically. The expression levels of CDX1, CDX2, Sonic hedgehog (SHH), and SOX2 were evaluated based on H. pylori eradication and the development of metachronous lesions. Results: The eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.036). Opentype atrophy (P=0.003) and moderate-to-severe IM (P=0.001) occurred more frequently in the metachronous group. In patients with an initial diagnosis of dysplasia, the eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.002). In addition, open-type atrophy was more frequent in the metachronous group (P=0.047). In patients with an initial diagnosis of carcinoma, moderate-to-severe IM occurred more frequently in the metachronous group (P=0.003); however, the eradication failure rate was not significantly different between the two groups. SHH and SOX2 expression was increased, and CDX2 expression was decreased in the nonmetachronous group after eradication (P<0.05). Conclusions: Open-type atrophy, moderate-to-severe IM, and H. pylori eradication failure were significantly associated with metachronous lesions. However, eradication failure was significantly associated with dysplasia, but not carcinoma, in the metachronous group. Thus, H. pylori eradication may play an important role in preventing metachronous lesions after ER for precancerous lesions before carcinomatous transformation.

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DO - 10.5230/jgc.2015.15.4.246

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JO - Journal of Gastric Cancer

JF - Journal of Gastric Cancer

SN - 2093-582X

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