Abstract
Background and Aim: It remains unclear whether Helicobacter pylori eradication therapy affects the healing rate of iatrogenic ulcers following endoscopic mucosal resection (EMR) for gastric tumors. The aim of our study was to prospectively evaluate the effect of H. pylori eradication therapy on gastric ulcer healing after EMR. Methods: After EMR, patients were randomly assigned to either the H. pylori eradication group (Hp group) (lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg, twice a day for 7 days) or the noneradication group (proton pump inhibitor, PPI group) (lansoprazole 30 mg, twice a day for 7 days). Four weeks after EMR, the ulcer stages and size were compared between the two groups. Moreover, ulcer-related symptoms, bleeding rates, adverse effects, and drug compliance were compared. Results: A total of 64 patients were enrolled. Of these, 17 patients were excluded from the study. The two groups were comparable in terms of baseline clinicopathologic characteristics. Four weeks after EMR, the two groups did not differ with respect to ulcer stage (p =.475) or ulcer-related symptoms (p =.399). However, the ulcer reduction ratio was significantly higher in the Hp group (0.028 ± 0.024 vs. 0.065 ± 0.055, p <.05). No differences were observed between the two groups with regard to drug compliance, adverse drug event rates, or bleeding rates. Conclusions: Our results suggest that H. pylori eradication therapy might improve the ulcer healing rate after EMR.
| Original language | English |
|---|---|
| Pages (from-to) | 564-571 |
| Number of pages | 8 |
| Journal | Helicobacter |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2008 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
- Infectious Diseases
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Helicobacter pylori eradication therapy may facilitate gastric ulcer healing after endoscopic mucosal resection : A prospective randomized study. / Cheon, JaeHee; Kim, Jie-Hyun; Lee, SangKil; Kim, Tae Il; Kim, Won Ho; Lee, Yongchan.
In: Helicobacter, Vol. 13, No. 6, 01.12.2008, p. 564-571.Research output: Contribution to journal › Article
TY - JOUR
T1 - Helicobacter pylori eradication therapy may facilitate gastric ulcer healing after endoscopic mucosal resection
T2 - A prospective randomized study
AU - Cheon, JaeHee
AU - Kim, Jie-Hyun
AU - Lee, SangKil
AU - Kim, Tae Il
AU - Kim, Won Ho
AU - Lee, Yongchan
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Background and Aim: It remains unclear whether Helicobacter pylori eradication therapy affects the healing rate of iatrogenic ulcers following endoscopic mucosal resection (EMR) for gastric tumors. The aim of our study was to prospectively evaluate the effect of H. pylori eradication therapy on gastric ulcer healing after EMR. Methods: After EMR, patients were randomly assigned to either the H. pylori eradication group (Hp group) (lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg, twice a day for 7 days) or the noneradication group (proton pump inhibitor, PPI group) (lansoprazole 30 mg, twice a day for 7 days). Four weeks after EMR, the ulcer stages and size were compared between the two groups. Moreover, ulcer-related symptoms, bleeding rates, adverse effects, and drug compliance were compared. Results: A total of 64 patients were enrolled. Of these, 17 patients were excluded from the study. The two groups were comparable in terms of baseline clinicopathologic characteristics. Four weeks after EMR, the two groups did not differ with respect to ulcer stage (p =.475) or ulcer-related symptoms (p =.399). However, the ulcer reduction ratio was significantly higher in the Hp group (0.028 ± 0.024 vs. 0.065 ± 0.055, p <.05). No differences were observed between the two groups with regard to drug compliance, adverse drug event rates, or bleeding rates. Conclusions: Our results suggest that H. pylori eradication therapy might improve the ulcer healing rate after EMR.
AB - Background and Aim: It remains unclear whether Helicobacter pylori eradication therapy affects the healing rate of iatrogenic ulcers following endoscopic mucosal resection (EMR) for gastric tumors. The aim of our study was to prospectively evaluate the effect of H. pylori eradication therapy on gastric ulcer healing after EMR. Methods: After EMR, patients were randomly assigned to either the H. pylori eradication group (Hp group) (lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg, twice a day for 7 days) or the noneradication group (proton pump inhibitor, PPI group) (lansoprazole 30 mg, twice a day for 7 days). Four weeks after EMR, the ulcer stages and size were compared between the two groups. Moreover, ulcer-related symptoms, bleeding rates, adverse effects, and drug compliance were compared. Results: A total of 64 patients were enrolled. Of these, 17 patients were excluded from the study. The two groups were comparable in terms of baseline clinicopathologic characteristics. Four weeks after EMR, the two groups did not differ with respect to ulcer stage (p =.475) or ulcer-related symptoms (p =.399). However, the ulcer reduction ratio was significantly higher in the Hp group (0.028 ± 0.024 vs. 0.065 ± 0.055, p <.05). No differences were observed between the two groups with regard to drug compliance, adverse drug event rates, or bleeding rates. Conclusions: Our results suggest that H. pylori eradication therapy might improve the ulcer healing rate after EMR.
UR - http://www.scopus.com/inward/record.url?scp=55949108136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55949108136&partnerID=8YFLogxK
U2 - 10.1111/j.1523-5378.2008.00647.x
DO - 10.1111/j.1523-5378.2008.00647.x
M3 - Article
C2 - 19166423
AN - SCOPUS:55949108136
VL - 13
SP - 564
EP - 571
JO - Helicobacter
JF - Helicobacter
SN - 1083-4389
IS - 6
ER -