Hemoconcentration is a good prognostic predictor for clinical outcomes in acute heart failure: Data from the Korean Heart Failure (KorHF) Registry

Jaewon Oh, Seok Min Kang, Namki Hong, Jong Chan Youn, Seongwoo Han, Eun Seok Jeon, Myeong Chan Cho, Jae Joong Kim, Byung Su Yoo, Shung Chull Chae, Byung Hee Oh, Dong Ju Choi, Myung Mook Lee, Kyu Hyung Ryu

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Abstract

Background Hemoconcentration is a surrogate marker of effective decongestion and diuresis therapy. Recently, hemoconcentration has been associated with decreased mortality and rehospitalization in heart failure (HF) patients. However, the prognostic power of hemoconcentration in a large sample-sized HF cohort was limited until now. Methods and results We analyzed data from hospitalized patients with acute heart failure (AHF) that were enrolled in the Korean Heart Failure Registry(n = 2,357). The primary end point was a composite of all-cause mortality and HF rehospitalization during the follow-up period (median = 347, interquartile range = 78-744 days).Hemoconcentration, defined as an increased hemoglobin level between admission and discharge, was presented in 1,016 AHF patients (43.1%). In multivariable logistic regression, hemoglobin, total cholesterol, and serum glucose levels at admission, and ischemic HF, were significant determinants for hemoconcentration occurrence. The Kaplan-Meier curve showed that event-free survival was significantly higher in the hemoconcentration group compared to the non-hemoconcentration group (65.1% vs. 58.1%, log rank p < 0.001). In multiple Cox proportional hazard analysis, hemoconcentration was an independent predictor of the primary end point after adjusting for other HF risk factors (hazard ratio = 0.671, 95% confidence interval = 0.564-0.798, p < 0.001). Conclusions Hemoconcentration during hospitalization was a prognostic marker of fewer clinical events in the AHF cohort. Therefore, this novel surrogate marker will help in the risk stratification of AHF patients.

Original languageEnglish
Pages (from-to)4739-4743
Number of pages5
JournalInternational Journal of Cardiology
Volume168
Issue number5
DOIs
Publication statusPublished - 2013 Oct 12

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Oh, J., Kang, S. M., Hong, N., Youn, J. C., Han, S., Jeon, E. S., Cho, M. C., Kim, J. J., Yoo, B. S., Chae, S. C., Oh, B. H., Choi, D. J., Lee, M. M., & Ryu, K. H. (2013). Hemoconcentration is a good prognostic predictor for clinical outcomes in acute heart failure: Data from the Korean Heart Failure (KorHF) Registry. International Journal of Cardiology, 168(5), 4739-4743. https://doi.org/10.1016/j.ijcard.2013.07.241