TY - JOUR
T1 - Hemodynamic Effects of Tachycardia in Patients with Relaxation Abnormality
T2 - Abnormal Stroke Volume Response as an Overlooked Mechanism of Dyspnea Associated with Tachycardia in Diastolic Heart Failure
AU - Sohn, Dae Won
AU - Kim, Hyung Kwan
AU - Park, Jin Shik
AU - Chang, Hyuk Jae
AU - Kim, Yong Jin
AU - Zo, Zoo Hee
AU - Oh, Byung Hee
AU - Park, Young Bae
AU - Choi, Yun Shik
N1 - Funding Information:
Supported in part by a research grant from the Seoul National University Hospital (No. 04-2003-020-0).
PY - 2007/2
Y1 - 2007/2
N2 - Background: Prevention of tachycardia is an important therapeutic strategy in patients with relaxation abnormality. Methods: Eleven patients with stable relaxation abnormality (group 1) and 8 healthy individuals (group 2) were enrolled. Left ventricular (LV) mean diastolic pressure, LV dimensions, stroke volume (SV), and LV ejection, filling, and isovolumic times between right atrial pacing rates of 80 and 120/min were compared. Results: Both groups 1 and 2 showed significant decreases in LV mean diastolic pressure when heart rate (HR) increased. At a HR of 80/min, no significant difference was noted between groups 1 and 2 in SV (51.4 ± 13.0 vs 45.2 ± 9.0 mL, P = .35). However, a decrement in SV between a HR of 80 and 120/min was significantly greater for group 1. Therefore, group 1 showed a significantly lower SV (30.2 ± 7.1 vs 40.1 ± 6.9 mL, P < .05) at a HR of 120/min. In terms of time intervals between HRs of 80 and 120/min, group 1 showed a significantly greater reduction in LV ejection time (84.5 ± 20.1 vs 30.0 ± 34.6 milliseconds, P < .005) and a smaller reduction in LV filling time (106.4 ± 38.5 vs 166.3 ± 30.7 milliseconds, P < .005) than group 2. Conclusions: Results of our study suggest that an inadequate SV response to tachycardia may play an important role in the production of dyspnea associated with tachycardia in these patients.
AB - Background: Prevention of tachycardia is an important therapeutic strategy in patients with relaxation abnormality. Methods: Eleven patients with stable relaxation abnormality (group 1) and 8 healthy individuals (group 2) were enrolled. Left ventricular (LV) mean diastolic pressure, LV dimensions, stroke volume (SV), and LV ejection, filling, and isovolumic times between right atrial pacing rates of 80 and 120/min were compared. Results: Both groups 1 and 2 showed significant decreases in LV mean diastolic pressure when heart rate (HR) increased. At a HR of 80/min, no significant difference was noted between groups 1 and 2 in SV (51.4 ± 13.0 vs 45.2 ± 9.0 mL, P = .35). However, a decrement in SV between a HR of 80 and 120/min was significantly greater for group 1. Therefore, group 1 showed a significantly lower SV (30.2 ± 7.1 vs 40.1 ± 6.9 mL, P < .05) at a HR of 120/min. In terms of time intervals between HRs of 80 and 120/min, group 1 showed a significantly greater reduction in LV ejection time (84.5 ± 20.1 vs 30.0 ± 34.6 milliseconds, P < .005) and a smaller reduction in LV filling time (106.4 ± 38.5 vs 166.3 ± 30.7 milliseconds, P < .005) than group 2. Conclusions: Results of our study suggest that an inadequate SV response to tachycardia may play an important role in the production of dyspnea associated with tachycardia in these patients.
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U2 - 10.1016/j.echo.2006.11.006
DO - 10.1016/j.echo.2006.11.006
M3 - Article
C2 - 17275703
AN - SCOPUS:33846598877
SN - 0894-7317
VL - 20
SP - 171
EP - 176
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 2
ER -