Hemodynamic Effects of Tachycardia in Patients with Relaxation Abnormality: Abnormal Stroke Volume Response as an Overlooked Mechanism of Dyspnea Associated with Tachycardia in Diastolic Heart Failure

Dae Won Sohn, Hyung Kwan Kim, Jin Shik Park, Hyuk Jae Chang, Yong Jin Kim, Zoo Hee Zo, Byung Hee Oh, Young Bae Park, Yun Shik Choi

Research output: Contribution to journalArticle

10 Citations (Scopus)


Background: Prevention of tachycardia is an important therapeutic strategy in patients with relaxation abnormality. Methods: Eleven patients with stable relaxation abnormality (group 1) and 8 healthy individuals (group 2) were enrolled. Left ventricular (LV) mean diastolic pressure, LV dimensions, stroke volume (SV), and LV ejection, filling, and isovolumic times between right atrial pacing rates of 80 and 120/min were compared. Results: Both groups 1 and 2 showed significant decreases in LV mean diastolic pressure when heart rate (HR) increased. At a HR of 80/min, no significant difference was noted between groups 1 and 2 in SV (51.4 ± 13.0 vs 45.2 ± 9.0 mL, P = .35). However, a decrement in SV between a HR of 80 and 120/min was significantly greater for group 1. Therefore, group 1 showed a significantly lower SV (30.2 ± 7.1 vs 40.1 ± 6.9 mL, P < .05) at a HR of 120/min. In terms of time intervals between HRs of 80 and 120/min, group 1 showed a significantly greater reduction in LV ejection time (84.5 ± 20.1 vs 30.0 ± 34.6 milliseconds, P < .005) and a smaller reduction in LV filling time (106.4 ± 38.5 vs 166.3 ± 30.7 milliseconds, P < .005) than group 2. Conclusions: Results of our study suggest that an inadequate SV response to tachycardia may play an important role in the production of dyspnea associated with tachycardia in these patients.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalJournal of the American Society of Echocardiography
Issue number2
Publication statusPublished - 2007 Feb 1


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this