Hemoglobin-mimetic oxygen adsorbent prepared via self-assembly of cysteinyl bolaamphiphiles

Chaemyeong Lee, Min Chul Kim, Sang Yup Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In this study, a novel cysteinyl bolaamphiphilic molecule was synthesized and its self-assembled planar suprastructure was applied as a biomimetic matrix to create a hemoglobin-mimetic oxygen adsorbent that exploits the ability of cysteine thiols to bind hemin. Self-assembly of the cysteinyl bolaamphiphilic molecule exposed cysteine thiols on its surface in the presence of β-mercaptoethanol, known to reduce disulfide bonds, without which, helically coiled structures were generated. The self-assembled planar structure was used as a soft matrix to create a hemoglobin-mimetic oxygen adsorbent. The surface-exposed cysteine thiols were used to attach hemin, producing a hemin-bound, planar structure mimicking hemoglobin. This hemoglobin mimic strongly adsorbed oxygen and remained stable up to 50 °C. The cysteinyl bolaamphiphile self-assembled structure provided a biomimetic platform that allowed for the association of biological substances in a manner similar to natural proteins.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume142
DOIs
Publication statusPublished - 2016 Jun 1

Bibliographical note

Funding Information:
This work was supported by a grant from the Korean Research Foundation funded by the Korean Government ( NRF-2013R1A1A2006459 ) and by the Human Resources Program in Energy Technology of the Korea Institute of Energy Technology Evaluation and Planning (KETEP), which was provided with financial resources from the Ministry of Trade, Industry & Energy, Republic of Korea (No. 20154010200810 ).

Publisher Copyright:
© 2016 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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