Hemoglobin-mimetic oxygen adsorbent prepared via self-assembly of cysteinyl bolaamphiphiles

Chaemyeong Lee, Min Chul Kim, Sangyup Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this study, a novel cysteinyl bolaamphiphilic molecule was synthesized and its self-assembled planar suprastructure was applied as a biomimetic matrix to create a hemoglobin-mimetic oxygen adsorbent that exploits the ability of cysteine thiols to bind hemin. Self-assembly of the cysteinyl bolaamphiphilic molecule exposed cysteine thiols on its surface in the presence of β-mercaptoethanol, known to reduce disulfide bonds, without which, helically coiled structures were generated. The self-assembled planar structure was used as a soft matrix to create a hemoglobin-mimetic oxygen adsorbent. The surface-exposed cysteine thiols were used to attach hemin, producing a hemin-bound, planar structure mimicking hemoglobin. This hemoglobin mimic strongly adsorbed oxygen and remained stable up to 50 °C. The cysteinyl bolaamphiphile self-assembled structure provided a biomimetic platform that allowed for the association of biological substances in a manner similar to natural proteins.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume142
DOIs
Publication statusPublished - 2016 Jun 1

Fingerprint

Hemoglobin
hemoglobin
adsorbents
Adsorbents
Self assembly
Hemin
self assembly
cysteine
Hemoglobins
Sulfhydryl Compounds
thiols
Oxygen
Cysteine
Biomimetics
planar structures
biomimetics
oxygen
Molecules
Mercaptoethanol
disulfides

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

@article{5b39446462e84a2d86864f18a95d083c,
title = "Hemoglobin-mimetic oxygen adsorbent prepared via self-assembly of cysteinyl bolaamphiphiles",
abstract = "In this study, a novel cysteinyl bolaamphiphilic molecule was synthesized and its self-assembled planar suprastructure was applied as a biomimetic matrix to create a hemoglobin-mimetic oxygen adsorbent that exploits the ability of cysteine thiols to bind hemin. Self-assembly of the cysteinyl bolaamphiphilic molecule exposed cysteine thiols on its surface in the presence of β-mercaptoethanol, known to reduce disulfide bonds, without which, helically coiled structures were generated. The self-assembled planar structure was used as a soft matrix to create a hemoglobin-mimetic oxygen adsorbent. The surface-exposed cysteine thiols were used to attach hemin, producing a hemin-bound, planar structure mimicking hemoglobin. This hemoglobin mimic strongly adsorbed oxygen and remained stable up to 50 °C. The cysteinyl bolaamphiphile self-assembled structure provided a biomimetic platform that allowed for the association of biological substances in a manner similar to natural proteins.",
author = "Chaemyeong Lee and Kim, {Min Chul} and Sangyup Lee",
year = "2016",
month = "6",
day = "1",
doi = "10.1016/j.colsurfb.2016.03.012",
language = "English",
volume = "142",
pages = "360--366",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",
publisher = "Elsevier",

}

Hemoglobin-mimetic oxygen adsorbent prepared via self-assembly of cysteinyl bolaamphiphiles. / Lee, Chaemyeong; Kim, Min Chul; Lee, Sangyup.

In: Colloids and Surfaces B: Biointerfaces, Vol. 142, 01.06.2016, p. 360-366.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hemoglobin-mimetic oxygen adsorbent prepared via self-assembly of cysteinyl bolaamphiphiles

AU - Lee, Chaemyeong

AU - Kim, Min Chul

AU - Lee, Sangyup

PY - 2016/6/1

Y1 - 2016/6/1

N2 - In this study, a novel cysteinyl bolaamphiphilic molecule was synthesized and its self-assembled planar suprastructure was applied as a biomimetic matrix to create a hemoglobin-mimetic oxygen adsorbent that exploits the ability of cysteine thiols to bind hemin. Self-assembly of the cysteinyl bolaamphiphilic molecule exposed cysteine thiols on its surface in the presence of β-mercaptoethanol, known to reduce disulfide bonds, without which, helically coiled structures were generated. The self-assembled planar structure was used as a soft matrix to create a hemoglobin-mimetic oxygen adsorbent. The surface-exposed cysteine thiols were used to attach hemin, producing a hemin-bound, planar structure mimicking hemoglobin. This hemoglobin mimic strongly adsorbed oxygen and remained stable up to 50 °C. The cysteinyl bolaamphiphile self-assembled structure provided a biomimetic platform that allowed for the association of biological substances in a manner similar to natural proteins.

AB - In this study, a novel cysteinyl bolaamphiphilic molecule was synthesized and its self-assembled planar suprastructure was applied as a biomimetic matrix to create a hemoglobin-mimetic oxygen adsorbent that exploits the ability of cysteine thiols to bind hemin. Self-assembly of the cysteinyl bolaamphiphilic molecule exposed cysteine thiols on its surface in the presence of β-mercaptoethanol, known to reduce disulfide bonds, without which, helically coiled structures were generated. The self-assembled planar structure was used as a soft matrix to create a hemoglobin-mimetic oxygen adsorbent. The surface-exposed cysteine thiols were used to attach hemin, producing a hemin-bound, planar structure mimicking hemoglobin. This hemoglobin mimic strongly adsorbed oxygen and remained stable up to 50 °C. The cysteinyl bolaamphiphile self-assembled structure provided a biomimetic platform that allowed for the association of biological substances in a manner similar to natural proteins.

UR - http://www.scopus.com/inward/record.url?scp=84960415517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960415517&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfb.2016.03.012

DO - 10.1016/j.colsurfb.2016.03.012

M3 - Article

C2 - 26970824

AN - SCOPUS:84960415517

VL - 142

SP - 360

EP - 366

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

ER -