Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1

Ai Guo Wang; Sang Beom Seo; Hyung Bae Moon; Hye Jun Shin; Dong Hoon Kim; Jin Man Kim; Tae Hoon Lee; Ho Jeong Kwon; Dae Yeul Yu; Dong Seok Lee

doi:10.1016/j.bbrc.2005.02.179

Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1

Ai Guo Wang, Sang Beom Seo, Hyung Bae Moon, Hye Jun Shin, Dong Hoon Kim, Jin Man Kim, Tae Hoon Lee, Ho Jeong Kwon, Dae Yeul Yu, Dong Seok Lee

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.

Original language	English
Pages (from-to)	461-466
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	330
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2005.02.179
Publication status	Published - 2005 May 6

Bibliographical note

Funding Information:
This work was supported by the 21st Century Frontier Functional Human Genome Project of Korea, Grant No. HGC0300324 and the Ministry of Health and Welfare of Korea, Grant No. 02-PJ2-PG1-CH12-0002.

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2005.02.179

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title = "Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1",

abstract = "It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.",

author = "Wang, {Ai Guo} and Seo, {Sang Beom} and Moon, {Hyung Bae} and Shin, {Hye Jun} and Kim, {Dong Hoon} and Kim, {Jin Man} and Lee, {Tae Hoon} and Kwon, {Ho Jeong} and Yu, {Dae Yeul} and Lee, {Dong Seok}",

note = "Funding Information: This work was supported by the 21st Century Frontier Functional Human Genome Project of Korea, Grant No. HGC0300324 and the Ministry of Health and Welfare of Korea, Grant No. 02-PJ2-PG1-CH12-0002.",

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AU - Wang, Ai Guo

AU - Seo, Sang Beom

AU - Moon, Hyung Bae

AU - Shin, Hye Jun

AU - Kim, Dong Hoon

AU - Kim, Jin Man

AU - Lee, Tae Hoon

AU - Kwon, Ho Jeong

AU - Yu, Dae Yeul

AU - Lee, Dong Seok

N1 - Funding Information: This work was supported by the 21st Century Frontier Functional Human Genome Project of Korea, Grant No. HGC0300324 and the Ministry of Health and Welfare of Korea, Grant No. 02-PJ2-PG1-CH12-0002.

PY - 2005/5/6

Y1 - 2005/5/6

N2 - It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.

AB - It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.

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Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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