It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 2005 May 6|
Bibliographical noteFunding Information:
This work was supported by the 21st Century Frontier Functional Human Genome Project of Korea, Grant No. HGC0300324 and the Ministry of Health and Welfare of Korea, Grant No. 02-PJ2-PG1-CH12-0002.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology