Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis

Moonyoung Kim, Soonkoo Baik, Chang Jin Yea, Il Young Lee, Hye Jung Kim, Kyong Won Park, Hearn Kook Kim, Ki Tae Suk, Jae Woo Kim, Hyunsoo Kim, Sang Ok Kwon, Seung Hwan Cha, Young Ju Kim, Sangbaek Koh, Sei Jin Chang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

OBJECTIVE: Portal hypertension is closely associated with serious complications of cirrhosis, which contribute to bad prognosis. Hepatocellular carcinoma (HCC) and low serum sodium (SNa) are manifestations of end-stage liver disease and are associated with poor survival in decompensated cirrhosis patients. We aimed to determine the relationship between hepatic venous pressure gradient (HVPG) and the development of HCC or low SNa in decompensated alcoholic cirrhosis patients. METHODS: Child-Pugh scores, Model for End-Stage Liver Disease scores, and HVPG at baseline, and the development of HCC or low SNa (SNa <130 mEq/l) during follow-up were analyzed prospectively in 170 patients with decompensated alcoholic cirrhosis from December 1999 to January 2008 (mean follow-up period of 33.9±27.9 months). The predictive value of different risk factors for the development of HCC and low SNa and survival were investigated. RESULTS: Twenty-four patients developed HCC during the follow-up period. In the multivariate analysis, only baseline HVPG greater than 15 mmHg was an independent predictive factor for the development of HCC (relative risk=1.128, P<0.05) and which showed a significantly shorter time for the development of HCC on the Kaplan-Meier analysis. Twenty patients developed low SNa during follow-up. Initial HVPG was also an independent predictive factor for the new development of low SNa in the multivariate analysis (relative risk=1.169, P<0.05) and which also showed significantly shorter times for the development of low SNa on the Kaplan-Meier analysis. CONCLUSION: In decompensated alcoholic cirrhosis, HVPG may be a useful predictive factor for the development of HCC and low SNa.

Original languageEnglish
Pages (from-to)1241-1246
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume21
Issue number11
DOIs
Publication statusPublished - 2009 Nov 1

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Alcoholic Liver Cirrhosis
Venous Pressure
Hyponatremia
Hepatocellular Carcinoma
Liver
End Stage Liver Disease
Kaplan-Meier Estimate
Fibrosis
Multivariate Analysis
Survival
Portal Hypertension
Sodium

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, Moonyoung ; Baik, Soonkoo ; Yea, Chang Jin ; Lee, Il Young ; Kim, Hye Jung ; Park, Kyong Won ; Kim, Hearn Kook ; Suk, Ki Tae ; Kim, Jae Woo ; Kim, Hyunsoo ; Kwon, Sang Ok ; Cha, Seung Hwan ; Kim, Young Ju ; Koh, Sangbaek ; Chang, Sei Jin. / Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis. In: European Journal of Gastroenterology and Hepatology. 2009 ; Vol. 21, No. 11. pp. 1241-1246.
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title = "Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis",
abstract = "OBJECTIVE: Portal hypertension is closely associated with serious complications of cirrhosis, which contribute to bad prognosis. Hepatocellular carcinoma (HCC) and low serum sodium (SNa) are manifestations of end-stage liver disease and are associated with poor survival in decompensated cirrhosis patients. We aimed to determine the relationship between hepatic venous pressure gradient (HVPG) and the development of HCC or low SNa in decompensated alcoholic cirrhosis patients. METHODS: Child-Pugh scores, Model for End-Stage Liver Disease scores, and HVPG at baseline, and the development of HCC or low SNa (SNa <130 mEq/l) during follow-up were analyzed prospectively in 170 patients with decompensated alcoholic cirrhosis from December 1999 to January 2008 (mean follow-up period of 33.9±27.9 months). The predictive value of different risk factors for the development of HCC and low SNa and survival were investigated. RESULTS: Twenty-four patients developed HCC during the follow-up period. In the multivariate analysis, only baseline HVPG greater than 15 mmHg was an independent predictive factor for the development of HCC (relative risk=1.128, P<0.05) and which showed a significantly shorter time for the development of HCC on the Kaplan-Meier analysis. Twenty patients developed low SNa during follow-up. Initial HVPG was also an independent predictive factor for the new development of low SNa in the multivariate analysis (relative risk=1.169, P<0.05) and which also showed significantly shorter times for the development of low SNa on the Kaplan-Meier analysis. CONCLUSION: In decompensated alcoholic cirrhosis, HVPG may be a useful predictive factor for the development of HCC and low SNa.",
author = "Moonyoung Kim and Soonkoo Baik and Yea, {Chang Jin} and Lee, {Il Young} and Kim, {Hye Jung} and Park, {Kyong Won} and Kim, {Hearn Kook} and Suk, {Ki Tae} and Kim, {Jae Woo} and Hyunsoo Kim and Kwon, {Sang Ok} and Cha, {Seung Hwan} and Kim, {Young Ju} and Sangbaek Koh and Chang, {Sei Jin}",
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Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis. / Kim, Moonyoung; Baik, Soonkoo; Yea, Chang Jin; Lee, Il Young; Kim, Hye Jung; Park, Kyong Won; Kim, Hearn Kook; Suk, Ki Tae; Kim, Jae Woo; Kim, Hyunsoo; Kwon, Sang Ok; Cha, Seung Hwan; Kim, Young Ju; Koh, Sangbaek; Chang, Sei Jin.

In: European Journal of Gastroenterology and Hepatology, Vol. 21, No. 11, 01.11.2009, p. 1241-1246.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis

AU - Kim, Moonyoung

AU - Baik, Soonkoo

AU - Yea, Chang Jin

AU - Lee, Il Young

AU - Kim, Hye Jung

AU - Park, Kyong Won

AU - Kim, Hearn Kook

AU - Suk, Ki Tae

AU - Kim, Jae Woo

AU - Kim, Hyunsoo

AU - Kwon, Sang Ok

AU - Cha, Seung Hwan

AU - Kim, Young Ju

AU - Koh, Sangbaek

AU - Chang, Sei Jin

PY - 2009/11/1

Y1 - 2009/11/1

N2 - OBJECTIVE: Portal hypertension is closely associated with serious complications of cirrhosis, which contribute to bad prognosis. Hepatocellular carcinoma (HCC) and low serum sodium (SNa) are manifestations of end-stage liver disease and are associated with poor survival in decompensated cirrhosis patients. We aimed to determine the relationship between hepatic venous pressure gradient (HVPG) and the development of HCC or low SNa in decompensated alcoholic cirrhosis patients. METHODS: Child-Pugh scores, Model for End-Stage Liver Disease scores, and HVPG at baseline, and the development of HCC or low SNa (SNa <130 mEq/l) during follow-up were analyzed prospectively in 170 patients with decompensated alcoholic cirrhosis from December 1999 to January 2008 (mean follow-up period of 33.9±27.9 months). The predictive value of different risk factors for the development of HCC and low SNa and survival were investigated. RESULTS: Twenty-four patients developed HCC during the follow-up period. In the multivariate analysis, only baseline HVPG greater than 15 mmHg was an independent predictive factor for the development of HCC (relative risk=1.128, P<0.05) and which showed a significantly shorter time for the development of HCC on the Kaplan-Meier analysis. Twenty patients developed low SNa during follow-up. Initial HVPG was also an independent predictive factor for the new development of low SNa in the multivariate analysis (relative risk=1.169, P<0.05) and which also showed significantly shorter times for the development of low SNa on the Kaplan-Meier analysis. CONCLUSION: In decompensated alcoholic cirrhosis, HVPG may be a useful predictive factor for the development of HCC and low SNa.

AB - OBJECTIVE: Portal hypertension is closely associated with serious complications of cirrhosis, which contribute to bad prognosis. Hepatocellular carcinoma (HCC) and low serum sodium (SNa) are manifestations of end-stage liver disease and are associated with poor survival in decompensated cirrhosis patients. We aimed to determine the relationship between hepatic venous pressure gradient (HVPG) and the development of HCC or low SNa in decompensated alcoholic cirrhosis patients. METHODS: Child-Pugh scores, Model for End-Stage Liver Disease scores, and HVPG at baseline, and the development of HCC or low SNa (SNa <130 mEq/l) during follow-up were analyzed prospectively in 170 patients with decompensated alcoholic cirrhosis from December 1999 to January 2008 (mean follow-up period of 33.9±27.9 months). The predictive value of different risk factors for the development of HCC and low SNa and survival were investigated. RESULTS: Twenty-four patients developed HCC during the follow-up period. In the multivariate analysis, only baseline HVPG greater than 15 mmHg was an independent predictive factor for the development of HCC (relative risk=1.128, P<0.05) and which showed a significantly shorter time for the development of HCC on the Kaplan-Meier analysis. Twenty patients developed low SNa during follow-up. Initial HVPG was also an independent predictive factor for the new development of low SNa in the multivariate analysis (relative risk=1.169, P<0.05) and which also showed significantly shorter times for the development of low SNa on the Kaplan-Meier analysis. CONCLUSION: In decompensated alcoholic cirrhosis, HVPG may be a useful predictive factor for the development of HCC and low SNa.

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JO - European Journal of Gastroenterology and Hepatology

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