Hepatitis C virus and antiviral drug resistance

Seungtaek Kim, KwangHyub Han, SangHoon Ahn

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Since its discovery in 1989, hepatitis C virus (HCV) has been intensively investigated to understand its biology and develop effective antiviral therapies. The efforts of the previous 25 years have resulted in a better understanding of the virus, and this was facilitated by the development of in vitro cell culture systems for HCV replication. Antiviral treatments and sustained virological responses have also improved from the early interferon monotherapy to the current all-oral regimens using direct-acting antivirals. However, antiviral resistance has become a critical issue in the treatment of chronic hepatitis C, similar to other chronic viral infections, and retreatment options following treatment failure have become important questions. Despite the clinical challenges in the management of chronic hepatitis C, substantial progress has been made in understanding HCV, which may facilitate the investigation of other closely related flaviviruses and lead to the development of antiviral agents against these human pathogens.

Original languageEnglish
Pages (from-to)890-895
Number of pages6
JournalGut and Liver
Volume10
Issue number6
DOIs
Publication statusPublished - 2016 Nov 1

Fingerprint

Viral Drug Resistance
Hepacivirus
Antiviral Agents
Chronic Hepatitis C
Flavivirus
Retreatment
Virus Diseases
Virus Replication
Treatment Failure
Interferons
Therapeutics
Cell Culture Techniques
Viruses

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

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Hepatitis C virus and antiviral drug resistance. / Kim, Seungtaek; Han, KwangHyub; Ahn, SangHoon.

In: Gut and Liver, Vol. 10, No. 6, 01.11.2016, p. 890-895.

Research output: Contribution to journalReview article

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