Heterogeneity of early-onset and ketosis-resistant diabetes in Korean subjects - Is it possible to determine cut-off age of early-onset type 2 diabetes?

Byung Wan Lee, Sang Yong Kim, Ji Youn Kim, Kyun Yung Cho, Yun Jae Chung, Yong Ki Min, Jae Hoon Chung, Moon Kyu Lee, Myung Shik Lee, Kwang Won Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To investigate the heterogeneity of early-onset and ketosis-resistant diabetes and to define a not-arbitrary cut-off age for early-onset diabetes based on its clinical and metabolic characteristics, and diabetes complications. Methods: We classified 1015 early-onset diabetes subjects aged 21-40 into four groups (group I, age at diagnosis 21-25 years; group II, 26-30; group III, 31-35; group IV, 36-40). Familial and diabetic history, statue of insulin secretion, metabolic parameters, and diabetes complications were analyzed. Results: No significant difference in family history or the rate of diabetic complication was found in the four groups. Subjects with a 21 to a 25-year-old diabetes onset had the lowest serum C-peptide levels, with 50% of the cumulative 24-h urine C-peptide levels of the other three groups (p < 0.0001). This group also had the lowest prevalence of hyperlipidemia and arterial hypertension (p < 0.01 and <0.0001, respectively). Group III was found to have a higher prevalence of insulin insufficiency and hypertension than group IV. Conclusion: Our data based on insulin secretory function and metabolic factors might suggest that a cut-off age of 26 years might be warranted in Korean patients. Korean early-onset type 2 diabetes patients tend to be non-obese and insulin secretory dysfunction.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume70
Issue number1
DOIs
Publication statusPublished - 2005 Oct 1

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Ketosis
Age of Onset
Type 2 Diabetes Mellitus
Diabetes Complications
Insulin
C-Peptide
Hypertension
Hyperlipidemias
Age Groups
History
Urine
Serum

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, Byung Wan ; Kim, Sang Yong ; Kim, Ji Youn ; Cho, Kyun Yung ; Chung, Yun Jae ; Min, Yong Ki ; Chung, Jae Hoon ; Lee, Moon Kyu ; Lee, Myung Shik ; Kim, Kwang Won. / Heterogeneity of early-onset and ketosis-resistant diabetes in Korean subjects - Is it possible to determine cut-off age of early-onset type 2 diabetes?. In: Diabetes Research and Clinical Practice. 2005 ; Vol. 70, No. 1. pp. 38-45.
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abstract = "Objective: To investigate the heterogeneity of early-onset and ketosis-resistant diabetes and to define a not-arbitrary cut-off age for early-onset diabetes based on its clinical and metabolic characteristics, and diabetes complications. Methods: We classified 1015 early-onset diabetes subjects aged 21-40 into four groups (group I, age at diagnosis 21-25 years; group II, 26-30; group III, 31-35; group IV, 36-40). Familial and diabetic history, statue of insulin secretion, metabolic parameters, and diabetes complications were analyzed. Results: No significant difference in family history or the rate of diabetic complication was found in the four groups. Subjects with a 21 to a 25-year-old diabetes onset had the lowest serum C-peptide levels, with 50{\%} of the cumulative 24-h urine C-peptide levels of the other three groups (p < 0.0001). This group also had the lowest prevalence of hyperlipidemia and arterial hypertension (p < 0.01 and <0.0001, respectively). Group III was found to have a higher prevalence of insulin insufficiency and hypertension than group IV. Conclusion: Our data based on insulin secretory function and metabolic factors might suggest that a cut-off age of 26 years might be warranted in Korean patients. Korean early-onset type 2 diabetes patients tend to be non-obese and insulin secretory dysfunction.",
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Heterogeneity of early-onset and ketosis-resistant diabetes in Korean subjects - Is it possible to determine cut-off age of early-onset type 2 diabetes? / Lee, Byung Wan; Kim, Sang Yong; Kim, Ji Youn; Cho, Kyun Yung; Chung, Yun Jae; Min, Yong Ki; Chung, Jae Hoon; Lee, Moon Kyu; Lee, Myung Shik; Kim, Kwang Won.

In: Diabetes Research and Clinical Practice, Vol. 70, No. 1, 01.10.2005, p. 38-45.

Research output: Contribution to journalArticle

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T1 - Heterogeneity of early-onset and ketosis-resistant diabetes in Korean subjects - Is it possible to determine cut-off age of early-onset type 2 diabetes?

AU - Lee, Byung Wan

AU - Kim, Sang Yong

AU - Kim, Ji Youn

AU - Cho, Kyun Yung

AU - Chung, Yun Jae

AU - Min, Yong Ki

AU - Chung, Jae Hoon

AU - Lee, Moon Kyu

AU - Lee, Myung Shik

AU - Kim, Kwang Won

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Objective: To investigate the heterogeneity of early-onset and ketosis-resistant diabetes and to define a not-arbitrary cut-off age for early-onset diabetes based on its clinical and metabolic characteristics, and diabetes complications. Methods: We classified 1015 early-onset diabetes subjects aged 21-40 into four groups (group I, age at diagnosis 21-25 years; group II, 26-30; group III, 31-35; group IV, 36-40). Familial and diabetic history, statue of insulin secretion, metabolic parameters, and diabetes complications were analyzed. Results: No significant difference in family history or the rate of diabetic complication was found in the four groups. Subjects with a 21 to a 25-year-old diabetes onset had the lowest serum C-peptide levels, with 50% of the cumulative 24-h urine C-peptide levels of the other three groups (p < 0.0001). This group also had the lowest prevalence of hyperlipidemia and arterial hypertension (p < 0.01 and <0.0001, respectively). Group III was found to have a higher prevalence of insulin insufficiency and hypertension than group IV. Conclusion: Our data based on insulin secretory function and metabolic factors might suggest that a cut-off age of 26 years might be warranted in Korean patients. Korean early-onset type 2 diabetes patients tend to be non-obese and insulin secretory dysfunction.

AB - Objective: To investigate the heterogeneity of early-onset and ketosis-resistant diabetes and to define a not-arbitrary cut-off age for early-onset diabetes based on its clinical and metabolic characteristics, and diabetes complications. Methods: We classified 1015 early-onset diabetes subjects aged 21-40 into four groups (group I, age at diagnosis 21-25 years; group II, 26-30; group III, 31-35; group IV, 36-40). Familial and diabetic history, statue of insulin secretion, metabolic parameters, and diabetes complications were analyzed. Results: No significant difference in family history or the rate of diabetic complication was found in the four groups. Subjects with a 21 to a 25-year-old diabetes onset had the lowest serum C-peptide levels, with 50% of the cumulative 24-h urine C-peptide levels of the other three groups (p < 0.0001). This group also had the lowest prevalence of hyperlipidemia and arterial hypertension (p < 0.01 and <0.0001, respectively). Group III was found to have a higher prevalence of insulin insufficiency and hypertension than group IV. Conclusion: Our data based on insulin secretory function and metabolic factors might suggest that a cut-off age of 26 years might be warranted in Korean patients. Korean early-onset type 2 diabetes patients tend to be non-obese and insulin secretory dysfunction.

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