High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function

COREA investigators

doi:10.1016/j.rmed.2019.02.010

High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function

COREA investigators

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: Low forced expiratory volume in 1 s (FEV ₁ ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV ₁ . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV ₁ . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV ₁ , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV ₁ < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV ₁ < 2.16 L and 9.8% of patients with FEV ₁ ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV ₁ (FEV ₁ ≥ 60% vs. FEV ₁ < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV ₁ seemed to show higher risk of AEs than those with near-normal FEV ₁ despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.

Original language	English
Pages (from-to)	38-44
Number of pages	7
Journal	Respiratory Medicine
Volume	150
DOIs	https://doi.org/10.1016/j.rmed.2019.02.010
Publication status	Published - 2019 Apr

Bibliographical note

Funding Information:
This research was supported by a grant awarded to the Korea Health Technology R&D Project via the Korea Health Industry Development Institute, which is funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1335). This research was also supported by the Basic Science Research Program via the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (2017R1D1A3B03034684).

Funding Information:
This research was supported by a grant awarded to the Korea Health Technology R&D Project via the Korea Health Industry Development Institute , which is funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1335 ). This research was also supported by the Basic Science Research Program via the National Research Foundation of Korea (NRF) , which is funded by the Ministry of Education ( 2017R1D1A3B03034684 ).

Publisher Copyright:
© 2019 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine

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10.1016/j.rmed.2019.02.010

Cite this

@article{169e883b1af146b6b5156ef2a2892220,

title = "High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function",

abstract = " Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test{\texttrademark} (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV 1 < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV 1 < 2.16 L and 9.8% of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60% vs. FEV 1 < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.",

author = "{COREA investigators} and Kwon, {Jae Woo} and Heewon Jung and Kim, {Sae Hoon} and Chang, {Yoon Seok} and Cho, {You Sook} and Nahm, {Dong Ho} and Jang, {An Soo} and Park, {Jung Won} and Yoon, {Ho Joo} and Cho, {Sang Heon} and Cho, {Young Joo} and Choi, {Byoung Whui} and Moon, {Hee Bom} and Kim, {Tae Bum}",

note = "Funding Information: This research was supported by a grant awarded to the Korea Health Technology R&D Project via the Korea Health Industry Development Institute, which is funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1335). This research was also supported by the Basic Science Research Program via the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (2017R1D1A3B03034684). Funding Information: This research was supported by a grant awarded to the Korea Health Technology R&D Project via the Korea Health Industry Development Institute , which is funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1335 ). This research was also supported by the Basic Science Research Program via the National Research Foundation of Korea (NRF) , which is funded by the Ministry of Education ( 2017R1D1A3B03034684 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = apr,

doi = "10.1016/j.rmed.2019.02.010",

language = "English",

volume = "150",

pages = "38--44",

journal = "British Journal of Tuberculosis and Diseases of the Chest",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function

AU - COREA investigators

AU - Kwon, Jae Woo

AU - Jung, Heewon

AU - Kim, Sae Hoon

AU - Chang, Yoon Seok

AU - Cho, You Sook

AU - Nahm, Dong Ho

AU - Jang, An Soo

AU - Park, Jung Won

AU - Yoon, Ho Joo

AU - Cho, Sang Heon

AU - Cho, Young Joo

AU - Choi, Byoung Whui

AU - Moon, Hee Bom

AU - Kim, Tae Bum

N1 - Funding Information: This research was supported by a grant awarded to the Korea Health Technology R&D Project via the Korea Health Industry Development Institute, which is funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1335). This research was also supported by the Basic Science Research Program via the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (2017R1D1A3B03034684). Funding Information: This research was supported by a grant awarded to the Korea Health Technology R&D Project via the Korea Health Industry Development Institute , which is funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1335 ). This research was also supported by the Basic Science Research Program via the National Research Foundation of Korea (NRF) , which is funded by the Ministry of Education ( 2017R1D1A3B03034684 ). Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/4

Y1 - 2019/4

N2 - Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV 1 < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV 1 < 2.16 L and 9.8% of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60% vs. FEV 1 < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.

AB - Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV 1 < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV 1 < 2.16 L and 9.8% of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60% vs. FEV 1 < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.

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UR - http://www.scopus.com/inward/citedby.url?scp=85061669728&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2019.02.010

DO - 10.1016/j.rmed.2019.02.010

M3 - Article

C2 - 30961949

AN - SCOPUS:85061669728

VL - 150

SP - 38

EP - 44

JO - British Journal of Tuberculosis and Diseases of the Chest

JF - British Journal of Tuberculosis and Diseases of the Chest

SN - 0954-6111

ER -

High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function

Abstract

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