Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV 1 < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV 1 < 2.16 L and 9.8% of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60% vs. FEV 1 < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.
Bibliographical noteFunding Information:
This research was supported by a grant awarded to the Korea Health Technology R&D Project via the Korea Health Industry Development Institute , which is funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1335 ). This research was also supported by the Basic Science Research Program via the National Research Foundation of Korea (NRF) , which is funded by the Ministry of Education ( 2017R1D1A3B03034684 ). Appendix A
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine