High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function

COREA investigators

Research output: Contribution to journalArticle

Abstract

Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV 1 < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV 1 < 2.16 L and 9.8% of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60% vs. FEV 1 < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalRespiratory Medicine
Volume150
DOIs
Publication statusPublished - 2019 Apr 1

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Asthma
Lung
Forced Expiratory Volume
Respiratory Function Tests

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

@article{169e883b1af146b6b5156ef2a2892220,
title = "High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function",
abstract = "Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24{\%} of patients with ACT <20 and FEV 1 < 60{\%} at baseline. Among patients with an ACT score ≥20, 3.4{\%} of patients with an FEV 1 < 2.16 L and 9.8{\%} of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60{\%} vs. FEV 1 < 60{\%}, 5.66{\%} vs. 8.51{\%}, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.",
author = "{COREA investigators} and Kwon, {Jae Woo} and Heewon Jung and Kim, {Sae Hoon} and Chang, {Yoon Seok} and Cho, {You Sook} and Nahm, {Dong Ho} and Jang, {An Soo} and Jungwon Park and Yoon, {Ho Joo} and Cho, {Sang Heon} and Cho, {Young Joo} and Choi, {Byoung Whui} and Moon, {Hee Bom} and Kim, {Tae Bum}",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.rmed.2019.02.010",
language = "English",
volume = "150",
pages = "38--44",
journal = "Respiratory Medicine",
issn = "0954-6111",
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High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function. / COREA investigators.

In: Respiratory Medicine, Vol. 150, 01.04.2019, p. 38-44.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High ACT score is not sufficient to reduce the risk of asthma exacerbations in asthma with low lung function

AU - COREA investigators

AU - Kwon, Jae Woo

AU - Jung, Heewon

AU - Kim, Sae Hoon

AU - Chang, Yoon Seok

AU - Cho, You Sook

AU - Nahm, Dong Ho

AU - Jang, An Soo

AU - Park, Jungwon

AU - Yoon, Ho Joo

AU - Cho, Sang Heon

AU - Cho, Young Joo

AU - Choi, Byoung Whui

AU - Moon, Hee Bom

AU - Kim, Tae Bum

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV 1 < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV 1 < 2.16 L and 9.8% of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60% vs. FEV 1 < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.

AB - Background: Low forced expiratory volume in 1 s (FEV 1 ) is a risk factor for asthma exacerbations (AEs). We aimed to determine if asthma control could reduce the future risk of AEs in patients with low FEV 1 . This study was conducted to evaluate the future risks of AEs within six months according to Asthma Control Test™ (ACT) score and FEV 1 . Methods: A total of 565 patients with asthma were enrolled from the COREA cohort. The ACT score, lung function test, and number of AEs were assessed at baseline, three-month follow-up, and six-month follow-up with conventional asthma treatments by asthma specialists in real clinical settings. Results: Female sex, low ACT score, low FEV 1 , low FVC, and AE history in the previous three months were related with increased AEs within six months. AEs during six-month follow-up occurred in 24% of patients with ACT <20 and FEV 1 < 60% at baseline. Among patients with an ACT score ≥20, 3.4% of patients with an FEV 1 < 2.16 L and 9.8% of patients with FEV 1 ≥ 2.16 L had experienced AEs (P = 0.01), although no differences were observed in the presence of AEs within six months according to the predicted FEV 1 (FEV 1 ≥ 60% vs. FEV 1 < 60%, 5.66% vs. 8.51%, P = 0.65). Conclusion: Patient with low FEV 1 seemed to show higher risk of AEs than those with near-normal FEV 1 despite ACT score ≥20 and asthma treatments. Therefore, treatment strategies that prevent AEs are needed in high-risk asthmatic patients.

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U2 - 10.1016/j.rmed.2019.02.010

DO - 10.1016/j.rmed.2019.02.010

M3 - Article

VL - 150

SP - 38

EP - 44

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

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